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NOD2 (Homo sapiens) in pENTR223.1 (Gateway donor/master vector)

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Explanation of Terms


Gene: Gene Symbol:  NOD2
Gene Name:  nucleotide-binding oligomerization domain containing 2
Sequence             
Original Clone ID: FLH269707.01L
Keyword: None
Species: Homo sapiens
Type: cDNA
Vector Name: pENTR223.1               Format:  FUSION
Source: The ORFeome Collaboration
Description: None
Comments: None
Mutation/
Discrepancy :
No / No
Publications: PMID: 26913471
Title: Fast Plasmid Based Protein Expression Analysis in Insect Cells Using an Automated SplitGFP Screen
Authors: The ORFeome Collaboration
HsCD00297035

Price:  Login for Pricing
AVAILABLE
No restriction
Special MTA: None

 

Insert sequence: 3120nts         Open reading frame : 35 to 3154
Reference Sequence Alignment

GTACAAAAAAGCAGAAGGGCCGTCAAGGCCCACCATGGGGGAAGAGGGTGGTTCAGCCTC
TCACGATGAGGAGGAAAGAGCAAGTGTCCTCCTCGGACATTCTCCGGGTTGTGAAATGTG
CTCGCAGGAGGCTTTTCAGGCACAGAGGAGCCAGCTGGTCGAGCTGCTGGTCTCAGGGTC
CCTGGAAGGCTTCGAGAGTGTCCTGGACTGGCTGCTGTCCTGGGAGGTCCTCTCCTGGGA
GGACTACGAGGGCTTCCACCTCCTGGGCCAGCCTCTCTCCCACTTGGCCAGGCGCCTTCT
GGACACCGTCTGGAATAAGGGTACTTGGGCCTGTCAGAAGCTCATCGCGGCTGCCCAAGA
AGCCCAGGCCGACAGCCAGTCCCCCAAGCTGCATGGCTGCTGGGACCCCCACTCGCTCCA
CCCAGCCCGAGACCTGCAGAGTCACCGGCCAGCCATTGTCAGGAGGCTCCACAGCCATGT
GGAGAACATGCTGGACCTGGCATGGGAGCGGGGTTTCGTCAGCCAGTATGAATGTGATGA
AATCAGGTTGCCGATCTTCACACCGTCCCAGAGGGCAAGAAGGCTGCTTGATCTTGCCAC
GGTGAAAGCGAATGGATTGGCTGCCTTCCTTCTACAACATGTTCAGGAATTACCAGTCCC
ATTGGCCCTGCCTTTGGAAGCTGCCACATGCAAGAAGTATATGGCCAAGCTGAGGACCAC
GGTGTCTGCTCAGTCTCGCTTCCTCAGTACCTATGATGGAGCAGAGACGCTCTGCCTGGA
GGACATATACACAGAGAATGTCCTGGAGGTCTGGGCAGATGTGGGCATGGCTGGACCCCC
GCAGAAGAGCCCAGCCACCCTGGGCCTGGAGGAGCTCTTCAGCACCCCTGGCCACCTCAA
TGACGATGCGGACACTGTGCTGGTGGTGGGTGAGGCGGGCAGTGGCAAGAGCACGCTCCT
GCAGCGGCTGCACTTGCTGTGGGCTGCAGGGCAAGACTTCCAGGAATTTCTCTTTGTCTT
CCCATTCAGCTGCCGGCAGCTGCAGTGCATGGCCAAACCACTCTCTGTGCGGACTCTACT
CTTTGAGCACTGCTGTTGGCCTGATGTTGGTCAAGAAGACATCTTCCAGTTACTCCTTGA
CCACCCTGACCGTGTCCTGTTAACCTTTGATGGCTTTGACGAGTTCAAGTTCAGGTTCAC
GGATCGTGAACGCCACTGCTCCCCGACCGACCCCACCTCTGTCCAGACCCTGCTCTTCAA
CCTTCTGCAGGGCAACCTGCTGAAGAATGCCCGCAAGGTGGTGACCAGCCGTCCGGCCGC
TGTGTCGGCGTTCCTCAGGAAGTACATCCGCACCGAGTTCAACCTCAAGGGCTTCTCTGA
ACAGGGCATCGAGCTGTACCTGAGGAAGCGCCATCATGAGCCCGGGGTGGCGGACCGCCT
CATCCGCCTGCTCCAAGAGACCTCAGCCCTGCACGGTTTGTGCCACCTGCCTGTCTTCTC
ATGGATGGTGTCCAAATGCCACCAGGAACTGTTGCTGCAGGAGGGGGGGTCCCCAAAGAC
CACTACAGATATGTACCTGCTGATTCTGCAGCATTTTCTGCTGCATGCCACCCCCCCAGA
CTCAGCTTCCCAAGGTCTGGGACCCAGTCTTCTTCGGGGCCGCCTCCCCACCCTCCTGCA
CCTGGGCAGACTGGCTCTGTGGGGCCTGGGCATGTGCTGCTACGTGTTCTCAGCCCAGCA
GCTCCAGGCAGCACAGGTCAGCCCTGATGACATTTCTCTTGGCTTCCTGGTGCGTGCCAA
AGGTGTCGTGCCAGGGAGTACGGCGCCCCTGGAATTCCTTCACATCACTTTCCAGTGCTT
CTTTGCCGCGTTCTACCTGGCACTCAGTGCTGATGTGCCACCAGCTTTGCTCAGACACCT
CTTCAATTGTGGCAGGCCAGGCAACTCACCAATGGCCAGGCTCCTGCCCACGATGTGCAT
CCAGGCCTCGGAGGGAAAGGACAGCAGCGTGGCAGCTTTGCTGCAGAAGGCCGAGCCGCA
CAACCTTCAGATCACAGCAGCCTTCCTGGCAGGGCTGTTGTCCCGGGAGCACTGGGGCCT
GCTGGCTGAGTGCCAGACATCTGAGAAGGCCCTGCTCCGGCGCCAGGCCTGTGCCCGCTG
GTGTCTGGCCCGCAGCCTCCGCAAGCACTTCCACTCCATCCCGCCAGCTGCACCGGGTGA
GGCCAAGAGCGTGCATGCCATGCCCGGGTTCATCTGGCTCATCCGGAGCCTGTACGAGAT
GCAGGAGGAGCGGCTGGCTCGGAAGGCTGCACGTGGCCTGAATGTTGGGCACCTCAAGTT
GACATTTTGCAGTGTGGGCCCCACTGAGTGTGCTGCCCTGGCCTTTGTGCTGCAGCACCT
CCGGCGGCCCGTGGCCCTGCAGCTGGACTACAACTCTGTGGGTGACATTGGCGTGGAGCA
GCTGCTGCCTTGCCTTGGTGTCTGCAAGGCTCTGTATTTGCGCGATAACAATATCTCAGA
CCGAGGCATCTGCAAGCTCATTGAATGTGCTCTTCACTGCGAGCAATTGCAGAAGTTAGC
TCTATTCAACAACAAATTGACTGACGGCTGTGCACACTCCATGGCTAAGCTCCTTGCATG
CAGGCAGAACTTCTTGGCATTGAGGCTGGGGAATAACTACATCACTGCCGCGGGAGCCCA
AGTGCTGGCCGAGGGGCTCCGAGGCAACACCTCCTTGCAGTTCCTGGGATTCTGGGGCAA
CAGAGTGGGTGACGAGGGGGCCCAGGCCCTGGCTGAAGCCTTGGGTGATCACCAGAGCTT
GAGGTGGCTCAGCCTGGTGGGGAACAACATTGGCAGTGTGGGTGCCCAAGCCTTGGCACT
GATGCTGGCAAAGAACGTCATGCTAGAAGAACTCTGCCTGGAGGAGAACCATCTCCAGGA
TGAAGGTGTATGTTCTCTCGCAGAAGGACTGAAGAAAAATTCAAGTTTGAAAATCCTGAA
GTTGTCCAATAACTGCATCACCTACCTAGGGGCAGAAGCCCTCCTGCAGGCCCTTGAAAG
GAATGACACCATCCTGGAAGTCTGGCTCCGAGGGAACACTTTCTCTCTAGAGGAGGTTGA
CAAGCTCGGCTGCAGGGACACCAGACTCTTGCTTTCAGGCCTCATGGGCCCAGCTTTCTT
GTAC


Coding Sequence Details
Insert Sequence Verified?: Y Verification Method: Sequence Verification
Reference Sequence Annotations:
Start on reference sequence 106
End on reference sequence 3228
Mutations:
None
Discrepancy:
None
5' Linker Sequence:
gtacaaaaaagcagaagGGCCGTCAAGGCCCACC

3' Linker Sequence:
TCAGGCCTCATGGgcccagctttcttg

 

 Recommended Growth Condition:

Distributed in bacterial strain : DH5-alpha T1 phage resistant
Antibiotic Selection: Host Type:  bacterial    Marker:  spectinomycin
Bacterial Selection Condition:  100 ug/mL spectinomycin
Growth Condition:  Growth at 37 degrees C in LB supplemented with 100 ug/mL spectinomycin.
Comments:  None
Protein Expression Results: None
Recommended expression in: Not Applicable
       DyNA Vector Map

         Powered by LabGenius

Vector Name: pENTR223.1

pENTR223.1 in advanced viewed

Synonyms: pDONR-223.1, pENTR223-star-Sfi
Sequencing Primer: Forward:  M13F
Reverse:  M13R
Description: Gateway type (lambda att-type) recombinational cloning entry (master) vector; spectinomycin resistance; recombinational cloning.
Comments: Additional information about this vector is available from the commercial website and at the ORFeome website http://orfeomecollaboration.org/vectors.php
Size (bp): 4311
Parent Vector: None
Empty Vector: None
Properties: Gateway, donor (entry), recombinational cloning
Author Name: Invitrogen
Publications: None
Vector Map:         Vector Sequence:
Sequence:

 



Vector Features:

Type Name Description Start Position End Position
MCS MCS MCS (Sfi sites flank the cassette present only in no insert form) 1265 1277
bacterial origin ori bacterial origin of replication 1 534
negative selection marker ccdB ccdB (no insert form only; lost in with insert form) 1312 1617
primer site M13 F M13 forward primer for insert sequencing 1113 1129
primer site T7 T7 Forward primer for insert sequencing 2902 2921
primer site M13 reverse M13 reverse primer for insert sequencing 2926 2942
recombination site attL1 attL1 recombination site 1165 1264
recombination site attL2 attL2 recombination site 2786 2885
selectable marker SpnR spectinomycin resistance gene 3154 4164
selectable marker CmR chlR (no insert form only; lost in with insert form) 1959 2618

 

  • Gene
  • Pathways
  • Protein
  • Clone
  • Organism
  • Genome
  • Reagents

Gene

 

Gene Symbol : NOD2
Symbol Nomenclature : NOD2
SYNONYM : ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1
Designation : NLR family, CARD domain containing 2|NOD-like receptor C2|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|caspase recruitment domain-containing protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2|nucleotide-binding oligomerization domain-containing protein 2
Full Nomenclature : nucleotide-binding oligomerization domain containing 2
GENEID : 64127
GI : 157170221
GenBank Accession : BC152737
HGNC : 5331
MIM : 605956
Vega : OTTHUMG00000133171
Target GenBank: NM_022162.1

 

Reference Sequence Alignment

  

HsCD00297035        GTACAAAAAAGCAGAAGGGCCGTCAAGGCCCACCATGGGGGAAGAGGGTGGTTCAGCCTC
NM_022162.1         ----------------------------------ATGGGGGAAGAGGGTGGTTCAGCCTC
XM_005256084.1      ------------------------------------------------------------
                                                                                

HsCD00297035        TCACGATGAGGAGGAAAGAGCAAGTGTCCTCCTCGGACATTCTCCGGGTTGTGAAATGTG
NM_022162.1         TCACGATGAGGAGGAAAGAGCAAGTGTCCTCCTCGGACATTCTCCGGGTTGTGAAATGTG
XM_005256084.1      -------------------------------------------------------ATGTG
                                                                           *****

HsCD00297035        CTCGCAGGAGGCTTTTCAGGCACAGAGGAGCCAGCTGGTCGAGCTGCTGGTCTCAGGGTC
NM_022162.1         CTCGCAGGAGGCTTTTCAGGCACAGAGGAGCCAGCTGGTCGAGCTGCTGGTCTCAGGGTC
XM_005256084.1      CTCGCAGGAGGCTTTTCAGGCACAGAGGAGCCAGCTGGTCGAGCTGCTGGTCTCAGGGTC
                    ************************************************************

HsCD00297035        CCTGGAAGGCTTCGAGAGTGTCCTGGACTGGCTGCTGTCCTGGGAGGTCCTCTCCTGGGA
NM_022162.1         CCTGGAAGGCTTCGAGAGTGTCCTGGACTGGCTGCTGTCCTGGGAGGTCCTCTCCTGGGA
XM_005256084.1      CCTGGAAGGCTTCGAGAGTGTCCTGGACTGGCTGCTGTCCTGGGAGGTCCTCTCCTGGGA
                    ************************************************************

HsCD00297035        GGACTACGAGGGCTTCCACCTCCTGGGCCAGCCTCTCTCCCACTTGGCCAGGCGCCTTCT
NM_022162.1         GGACTACGAGGGCTTCCACCTCCTGGGCCAGCCTCTCTCCCACTTGGCCAGGCGCCTTCT
XM_005256084.1      GGACTACGAGGGCTTCCACCTCCTGGGCCAGCCTCTCTCCCACTTGGCCAGGCGCCTTCT
                    ************************************************************

HsCD00297035        GGACACCGTCTGGAATAAGGGTACTTGGGCCTGTCAGAAGCTCATCGCGGCTGCCCAAGA
NM_022162.1         GGACACCGTCTGGAATAAGGGTACTTGGGCCTGTCAGAAGCTCATCGCGGCTGCCCAAGA
XM_005256084.1      GGACACCGTCTGGAATAAGGGTACTTGGGCCTGTCAGAAGCTCATCGCGGCTGCCCAAGA
                    ************************************************************

HsCD00297035        AGCCCAGGCCGACAGCCAGTCCCCCAAGCTGCATGGCTGCTGGGACCCCCACTCGCTCCA
NM_022162.1         AGCCCAGGCCGACAGCCAGTCCCCCAAGCTGCATGGCTGCTGGGACCCCCACTCGCTCCA
XM_005256084.1      AGCCCAGGCCGACAGCCAGTCCCCCAAGCTGCATGGCTGCTGGGACCCCCACTCGCTCCA
                    ************************************************************

HsCD00297035        CCCAGCCCGAGACCTGCAGAGTCACCGGCCAGCCATTGTCAGGAGGCTCCACAGCCATGT
NM_022162.1         CCCAGCCCGAGACCTGCAGAGTCACCGGCCAGCCATTGTCAGGAGGCTCCACAGCCATGT
XM_005256084.1      CCCAGCCCGAGACCTGCAGAGTCACCGGCCAGCCATTGTCAGGAGGCTCCACAGCCATGT
                    ************************************************************

HsCD00297035        GGAGAACATGCTGGACCTGGCATGGGAGCGGGGTTTCGTCAGCCAGTATGAATGTGATGA
NM_022162.1         GGAGAACATGCTGGACCTGGCATGGGAGCGGGGTTTCGTCAGCCAGTATGAATGTGATGA
XM_005256084.1      GGAGAACATGCTGGACCTGGCATGGGAGCGGGGTTTCGTCAGCCAGTATGAATGTGATGA
                    ************************************************************

HsCD00297035        AATCAGGTTGCCGATCTTCACACCGTCCCAGAGGGCAAGAAGGCTGCTTGATCTTGCCAC
NM_022162.1         AATCAGGTTGCCGATCTTCACACCGTCCCAGAGGGCAAGAAGGCTGCTTGATCTTGCCAC
XM_005256084.1      AATCAGGTTGCCGATCTTCACACCGTCCCAGAGGGCAAGAAGGCTGCTTGATCTTGCCAC
                    ************************************************************

HsCD00297035        GGTGAAAGCGAATGGATTGGCTGCCTTCCTTCTACAACATGTTCAGGAATTACCAGTCCC
NM_022162.1         GGTGAAAGCGAATGGATTGGCTGCCTTCCTTCTACAACATGTTCAGGAATTACCAGTCCC
XM_005256084.1      GGTGAAAGCGAATGGATTGGCTGCCTTCCTTCTACAACATGTTCAGGAATTACCAGTCCC
                    ************************************************************

HsCD00297035        ATTGGCCCTGCCTTTGGAAGCTGCCACATGCAAGAAGTATATGGCCAAGCTGAGGACCAC
NM_022162.1         ATTGGCCCTGCCTTTGGAAGCTGCCACATGCAAGAAGTATATGGCCAAGCTGAGGACCAC
XM_005256084.1      ATTGGCCCTGCCTTTGGAAGCTGCCACATGCAAGAAGTATATGGCCAAGCTGAGGACCAC
                    ************************************************************

HsCD00297035        GGTGTCTGCTCAGTCTCGCTTCCTCAGTACCTATGATGGAGCAGAGACGCTCTGCCTGGA
NM_022162.1         GGTGTCTGCTCAGTCTCGCTTCCTCAGTACCTATGATGGAGCAGAGACGCTCTGCCTGGA
XM_005256084.1      GGTGTCTGCTCAGTCTCGCTTCCTCAGTACCTATGATGGAGCAGAGACGCTCTGCCTGGA
                    ************************************************************

HsCD00297035        GGACATATACACAGAGAATGTCCTGGAGGTCTGGGCAGATGTGGGCATGGCTGGACCCCC
NM_022162.1         GGACATATACACAGAGAATGTCCTGGAGGTCTGGGCAGATGTGGGCATGGCTGGACCCCC
XM_005256084.1      GGACATATACACAGAGAATGTCCTGGAGGTCTGGGCAGATGTGGGCATGGCTGGACCCCC
                    ************************************************************

HsCD00297035        GCAGAAGAGCCCAGCCACCCTGGGCCTGGAGGAGCTCTTCAGCACCCCTGGCCACCTCAA
NM_022162.1         GCAGAAGAGCCCAGCCACCCTGGGCCTGGAGGAGCTCTTCAGCACCCCTGGCCACCTCAA
XM_005256084.1      GCAGAAGAGCCCAGCCACCCTGGGCCTGGAGGAGCTCTTCAGCACCCCTGGCCACCTCAA
                    ************************************************************

HsCD00297035        TGACGATGCGGACACTGTGCTGGTGGTGGGTGAGGCGGGCAGTGGCAAGAGCACGCTCCT
NM_022162.1         TGACGATGCGGACACTGTGCTGGTGGTGGGTGAGGCGGGCAGTGGCAAGAGCACGCTCCT
XM_005256084.1      TGACGATGCGGACACTGTGCTGGTGGTGGGTGAGGCGGGCAGTGGCAAGAGCACGCTCCT
                    ************************************************************

HsCD00297035        GCAGCGGCTGCACTTGCTGTGGGCTGCAGGGCAAGACTTCCAGGAATTTCTCTTTGTCTT
NM_022162.1         GCAGCGGCTGCACTTGCTGTGGGCTGCAGGGCAAGACTTCCAGGAATTTCTCTTTGTCTT
XM_005256084.1      GCAGCGGCTGCACTTGCTGTGGGCTGCAGGGCAAGACTTCCAGGAATTTCTCTTTGTCTT
                    ************************************************************

HsCD00297035        CCCATTCAGCTGCCGGCAGCTGCAGTGCATGGCCAAACCACTCTCTGTGCGGACTCTACT
NM_022162.1         CCCATTCAGCTGCCGGCAGCTGCAGTGCATGGCCAAACCACTCTCTGTGCGGACTCTACT
XM_005256084.1      CCCATTCAGCTGCCGGCAGCTGCAGTGCATGGCCAAACCACTCTCTGTGCGGACTCTACT
                    ************************************************************

HsCD00297035        CTTTGAGCACTGCTGTTGGCCTGATGTTGGTCAAGAAGACATCTTCCAGTTACTCCTTGA
NM_022162.1         CTTTGAGCACTGCTGTTGGCCTGATGTTGGTCAAGAAGACATCTTCCAGTTACTCCTTGA
XM_005256084.1      CTTTGAGCACTGCTGTTGGCCTGATGTTGGTCAAGAAGACATCTTCCAGTTACTCCTTGA
                    ************************************************************

HsCD00297035        CCACCCTGACCGTGTCCTGTTAACCTTTGATGGCTTTGACGAGTTCAAGTTCAGGTTCAC
NM_022162.1         CCACCCTGACCGTGTCCTGTTAACCTTTGATGGCTTTGACGAGTTCAAGTTCAGGTTCAC
XM_005256084.1      CCACCCTGACCGTGTCCTGTTAACCTTTGATGGCTTTGACGAGTTCAAGTTCAGGTTCAC
                    ************************************************************

HsCD00297035        GGATCGTGAACGCCACTGCTCCCCGACCGACCCCACCTCTGTCCAGACCCTGCTCTTCAA
NM_022162.1         GGATCGTGAACGCCACTGCTCCCCGACCGACCCCACCTCTGTCCAGACCCTGCTCTTCAA
XM_005256084.1      GGATCGTGAACGCCACTGCTCCCCGACCGACCCCACCTCTGTCCAGACCCTGCTCTTCAA
                    ************************************************************

HsCD00297035        CCTTCTGCAGGGCAACCTGCTGAAGAATGCCCGCAAGGTGGTGACCAGCCGTCCGGCCGC
NM_022162.1         CCTTCTGCAGGGCAACCTGCTGAAGAATGCCCGCAAGGTGGTGACCAGCCGTCCGGCCGC
XM_005256084.1      CCTTCTGCAGGGCAACCTGCTGAAGAATGCCCGCAAGGTGGTGACCAGCCGTCCGGCCGC
                    ************************************************************

HsCD00297035        TGTGTCGGCGTTCCTCAGGAAGTACATCCGCACCGAGTTCAACCTCAAGGGCTTCTCTGA
NM_022162.1         TGTGTCGGCGTTCCTCAGGAAGTACATCCGCACCGAGTTCAACCTCAAGGGCTTCTCTGA
XM_005256084.1      TGTGTCGGCGTTCCTCAGGAAGTACATCCGCACCGAGTTCAACCTCAAGGGCTTCTCTGA
                    ************************************************************

HsCD00297035        ACAGGGCATCGAGCTGTACCTGAGGAAGCGCCATCATGAGCCCGGGGTGGCGGACCGCCT
NM_022162.1         ACAGGGCATCGAGCTGTACCTGAGGAAGCGCCATCATGAGCCCGGGGTGGCGGACCGCCT
XM_005256084.1      ACAGGGCATCGAGCTGTACCTGAGGAAGCGCCATCATGAGCCCGGGGTGGCGGACCGCCT
                    ************************************************************

HsCD00297035        CATCCGCCTGCTCCAAGAGACCTCAGCCCTGCACGGTTTGTGCCACCTGCCTGTCTTCTC
NM_022162.1         CATCCGCCTGCTCCAAGAGACCTCAGCCCTGCACGGTTTGTGCCACCTGCCTGTCTTCTC
XM_005256084.1      CATCCGCCTGCTCCAAGAGACCTCAGCCCTGCACGGTTTGTGCCACCTGCCTGTCTTCTC
                    ************************************************************

HsCD00297035        ATGGATGGTGTCCAAATGCCACCAGGAACTGTTGCTGCAGGAGGGGGGGTCCCCAAAGAC
NM_022162.1         ATGGATGGTGTCCAAATGCCACCAGGAACTGTTGCTGCAGGAGGGGGGGTCCCCAAAGAC
XM_005256084.1      ATGGATGGTGTCCAAATGCCACCAGGAACTGTTGCTGCAGGAGGGGGGGTCCCCAAAGAC
                    ************************************************************

HsCD00297035        CACTACAGATATGTACCTGCTGATTCTGCAGCATTTTCTGCTGCATGCCACCCCCCCAGA
NM_022162.1         CACTACAGATATGTACCTGCTGATTCTGCAGCATTTTCTGCTGCATGCCACCCCCCCAGA
XM_005256084.1      CACTACAGATATGTACCTGCTGATTCTGCAGCATTTTCTGCTGCATGCCACCCCCCCAGA
                    ************************************************************

HsCD00297035        CTCAGCTTCCCAAGGTCTGGGACCCAGTCTTCTTCGGGGCCGCCTCCCCACCCTCCTGCA
NM_022162.1         CTCAGCTTCCCAAGGTCTGGGACCCAGTCTTCTTCGGGGCCGCCTCCCCACCCTCCTGCA
XM_005256084.1      CTCAGCTTCCCAAGGTCTGGGACCCAGTCTTCTTCGGGGCCGCCTCCCCACCCTCCTGCA
                    ************************************************************

HsCD00297035        CCTGGGCAGACTGGCTCTGTGGGGCCTGGGCATGTGCTGCTACGTGTTCTCAGCCCAGCA
NM_022162.1         CCTGGGCAGACTGGCTCTGTGGGGCCTGGGCATGTGCTGCTACGTGTTCTCAGCCCAGCA
XM_005256084.1      CCTGGGCAGACTGGCTCTGTGGGGCCTGGGCATGTGCTGCTACGTGTTCTCAGCCCAGCA
                    ************************************************************

HsCD00297035        GCTCCAGGCAGCACAGGTCAGCCCTGATGACATTTCTCTTGGCTTCCTGGTGCGTGCCAA
NM_022162.1         GCTCCAGGCAGCACAGGTCAGCCCTGATGACATTTCTCTTGGCTTCCTGGTGCGTGCCAA
XM_005256084.1      GCTCCAGGCAGCACAGGTCAGCCCTGATGACATTTCTCTTGGCTTCCTGGTGCGTGCCAA
                    ************************************************************

HsCD00297035        AGGTGTCGTGCCAGGGAGTACGGCGCCCCTGGAATTCCTTCACATCACTTTCCAGTGCTT
NM_022162.1         AGGTGTCGTGCCAGGGAGTACGGCGCCCCTGGAATTCCTTCACATCACTTTCCAGTGCTT
XM_005256084.1      AGGTGTCGTGCCAGGGAGTACGGCGCCCCTGGAATTCCTTCACATCACTTTCCAGTGCTT
                    ************************************************************

HsCD00297035        CTTTGCCGCGTTCTACCTGGCACTCAGTGCTGATGTGCCACCAGCTTTGCTCAGACACCT
NM_022162.1         CTTTGCCGCGTTCTACCTGGCACTCAGTGCTGATGTGCCACCAGCTTTGCTCAGACACCT
XM_005256084.1      CTTTGCCGCGTTCTACCTGGCACTCAGTGCTGATGTGCCACCAGCTTTGCTCAGACACCT
                    ************************************************************

HsCD00297035        CTTCAATTGTGGCAGGCCAGGCAACTCACCAATGGCCAGGCTCCTGCCCACGATGTGCAT
NM_022162.1         CTTCAATTGTGGCAGGCCAGGCAACTCACCAATGGCCAGGCTCCTGCCCACGATGTGCAT
XM_005256084.1      CTTCAATTGTGGCAGGCCAGGCAACTCACCAATGGCCAGGCTCCTGCCCACGATGTGCAT
                    ************************************************************

HsCD00297035        CCAGGCCTCGGAGGGAAAGGACAGCAGCGTGGCAGCTTTGCTGCAGAAGGCCGAGCCGCA
NM_022162.1         CCAGGCCTCGGAGGGAAAGGACAGCAGCGTGGCAGCTTTGCTGCAGAAGGCCGAGCCGCA
XM_005256084.1      CCAGGCCTCGGAGGGAAAGGACAGCAGCGTGGCAGCTTTGCTGCAGAAGGCCGAGCCGCA
                    ************************************************************

HsCD00297035        CAACCTTCAGATCACAGCAGCCTTCCTGGCAGGGCTGTTGTCCCGGGAGCACTGGGGCCT
NM_022162.1         CAACCTTCAGATCACAGCAGCCTTCCTGGCAGGGCTGTTGTCCCGGGAGCACTGGGGCCT
XM_005256084.1      CAACCTTCAGATCACAGCAGCCTTCCTGGCAGGGCTGTTGTCCCGGGAGCACTGGGGCCT
                    ************************************************************

HsCD00297035        GCTGGCTGAGTGCCAGACATCTGAGAAGGCCCTGCTCCGGCGCCAGGCCTGTGCCCGCTG
NM_022162.1         GCTGGCTGAGTGCCAGACATCTGAGAAGGCCCTGCTCCGGCGCCAGGCCTGTGCCCGCTG
XM_005256084.1      GCTGGCTGAGTGCCAGACATCTGAGAAGGCCCTGCTCCGGCGCCAGGCCTGTGCCCGCTG
                    ************************************************************

HsCD00297035        GTGTCTGGCCCGCAGCCTCCGCAAGCACTTCCACTCCATCCCGCCAGCTGCACCGGGTGA
NM_022162.1         GTGTCTGGCCCGCAGCCTCCGCAAGCACTTCCACTCCATCCCGCCAGCTGCACCGGGTGA
XM_005256084.1      GTGTCTGGCCCGCAGCCTCCGCAAGCACTTCCACTCCATCCCGCCAGCTGCACCGGGTGA
                    ************************************************************

HsCD00297035        GGCCAAGAGCGTGCATGCCATGCCCGGGTTCATCTGGCTCATCCGGAGCCTGTACGAGAT
NM_022162.1         GGCCAAGAGCGTGCATGCCATGCCCGGGTTCATCTGGCTCATCCGGAGCCTGTACGAGAT
XM_005256084.1      GGCCAAGAGCGTGCATGCCATGCCCGGGTTCATCTGGCTCATCCGGAGCCTGTACGAGAT
                    ************************************************************

HsCD00297035        GCAGGAGGAGCGGCTGGCTCGGAAGGCTGCACGTGGCCTGAATGTTGGGCACCTCAAGTT
NM_022162.1         GCAGGAGGAGCGGCTGGCTCGGAAGGCTGCACGTGGCCTGAATGTTGGGCACCTCAAGTT
XM_005256084.1      GCAGGAGGAGCGGCTGGCTCGGAAGGCTGCACGTGGCCTGAATGTTGGGCACCTCAAGTT
                    ************************************************************

HsCD00297035        GACATTTTGCAGTGTGGGCCCCACTGAGTGTGCTGCCCTGGCCTTTGTGCTGCAGCACCT
NM_022162.1         GACATTTTGCAGTGTGGGCCCCACTGAGTGTGCTGCCCTGGCCTTTGTGCTGCAGCACCT
XM_005256084.1      GACATTTTGCAGTGTGGGCCCCACTGAGTGTGCTGCCCTGGCCTTTGTGCTGCAGCACCT
                    ************************************************************

HsCD00297035        CCGGCGGCCCGTGGCCCTGCAGCTGGACTACAACTCTGTGGGTGACATTGGCGTGGAGCA
NM_022162.1         CCGGCGGCCCGTGGCCCTGCAGCTGGACTACAACTCTGTGGGTGACATTGGCGTGGAGCA
XM_005256084.1      CCGGCGGCCCGTGGCCCTGCAGCTGGACTACAACTCTGTGGGTGACATTGGCGTGGAGCA
                    ************************************************************

HsCD00297035        GCTGCTGCCTTGCCTTGGTGTCTGCAAGGCTCTGTATTTGCGCGATAACAATATCTCAGA
NM_022162.1         GCTGCTGCCTTGCCTTGGTGTCTGCAAGGCTCTGTATTTGCGCGATAACAATATCTCAGA
XM_005256084.1      GCTGCTGCCTTGCCTTGGTGTCTGCAAGGCTCTGTATTTGCGCGATAACAATATCTCAGA
                    ************************************************************

HsCD00297035        CCGAGGCATCTGCAAGCTCATTGAATGTGCTCTTCACTGCGAGCAATTGCAGAAGTTAGC
NM_022162.1         CCGAGGCATCTGCAAGCTCATTGAATGTGCTCTTCACTGCGAGCAATTGCAGAAGTTAGC
XM_005256084.1      CCGAGGCATCTGCAAGCTCATTGAATGTGCTCTTCACTGCGAGCAATTGCAGAAGTTAGC
                    ************************************************************

HsCD00297035        TCTATTCAACAACAAATTGACTGACGGCTGTGCACACTCCATGGCTAAGCTCCTTGCATG
NM_022162.1         TCTATTCAACAACAAATTGACTGACGGCTGTGCACACTCCATGGCTAAGCTCCTTGCATG
XM_005256084.1      TCTATTCAACAACAAATTGACTGACGGCTGTGCACACTCCATGGCTAAGCTCCTTGCATG
                    ************************************************************

HsCD00297035        CAGGCAGAACTTCTTGGCATTGAGGCTGGGGAATAACTACATCACTGCCGCGGGAGCCCA
NM_022162.1         CAGGCAGAACTTCTTGGCATTGAGGCTGGGGAATAACTACATCACTGCCGCGGGAGCCCA
XM_005256084.1      CAGGCAGAACTTCTTGGCATTGAGGCTGGGGAATAACTACATCACTGCCGCGGGAGCCCA
                    ************************************************************

HsCD00297035        AGTGCTGGCCGAGGGGCTCCGAGGCAACACCTCCTTGCAGTTCCTGGGATTCTGGGGCAA
NM_022162.1         AGTGCTGGCCGAGGGGCTCCGAGGCAACACCTCCTTGCAGTTCCTGGGATTCTGGGGCAA
XM_005256084.1      AGTGCTGGCCGAGGGGCTCCGAGGCAACACCTCCTTGCAGTTCCTGGGATTCTGGGGCAA
                    ************************************************************

HsCD00297035        CAGAGTGGGTGACGAGGGGGCCCAGGCCCTGGCTGAAGCCTTGGGTGATCACCAGAGCTT
NM_022162.1         CAGAGTGGGTGACGAGGGGGCCCAGGCCCTGGCTGAAGCCTTGGGTGATCACCAGAGCTT
XM_005256084.1      CAGAGTGGGTGACGAGGGGGCCCAGGCCCTGGCTGAAGCCTTGGGTGATCACCAGAGCTT
                    ************************************************************

HsCD00297035        GAGGTGGCTCAGCCTGGTGGGGAACAACATTGGCAGTGTGGGTGCCCAAGCCTTGGCACT
NM_022162.1         GAGGTGGCTCAGCCTGGTGGGGAACAACATTGGCAGTGTGGGTGCCCAAGCCTTGGCACT
XM_005256084.1      GAGGTGGCTCAGCCTGGTGGGGAACAACATTGGCAGTGTGGGTGCCCAAGCCTTGGCACT
                    ************************************************************

HsCD00297035        GATGCTGGCAAAGAACGTCATGCTAGAAGAACTCTGCCTGGAGGAGAACCATCTCCAGGA
NM_022162.1         GATGCTGGCAAAGAACGTCATGCTAGAAGAACTCTGCCTGGAGGAGAACCATCTCCAGGA
XM_005256084.1      GATGCTGGCAAAGAACGTCATGCTAGAAGAACTCTGCCTGGAGGAGAACCATCTCCAGGA
                    ************************************************************

HsCD00297035        TGAAGGTGTATGTTCTCTCGCAGAAGGACTGAAGAAAAATTCAAGTTTGAAAATCCTGAA
NM_022162.1         TGAAGGTGTATGTTCTCTCGCAGAAGGACTGAAGAAAAATTCAAGTTTGAAAATCCTGAA
XM_005256084.1      TGAAGGTGTATGTTCTCTCGCAGAAGGACTGAAGAAAAATTCAAGTTTGAAAATCCTGAA
                    ************************************************************

HsCD00297035        GTTGTCCAATAACTGCATCACCTACCTAGGGGCAGAAGCCCTCCTGCAGGCCCTTGAAAG
NM_022162.1         GTTGTCCAATAACTGCATCACCTACCTAGGGGCAGAAGCCCTCCTGCAGGCCCTTGAAAG
XM_005256084.1      GTTGTCCAATAACTGCATCACCTACCTAGGGGCAGAAGCCCTCCTGCAGGCCCTTGAAAG
                    ************************************************************

HsCD00297035        GAATGACACCATCCTGGAAGTCTGGCTCCGAGGGAACACTTTCTCTCTAGAGGAGGTTGA
NM_022162.1         GAATGACACCATCCTGGAAGTCTGGCTCCGAGGGAACACTTTCTCTCTAGAGGAGGTTGA
XM_005256084.1      GAATGACACCATCCTGGAAGTCTGGCTCCGAGGGAACACTTTCTCTCTAGAGGAGGTTGA
                    ************************************************************

HsCD00297035        CAAGCTCGGCTGCAGGGACACCAGACTCTTGCTTTCAGGCCTCATGGGCCCAGCTTTCTT
NM_022162.1         CAAGCTCGGCTGCAGGGACACCAGACTCTTGCTTTGA-----------------------
XM_005256084.1      CAAGCTCGGCTGCAGGGACACCAGACTCTTGCTTTGA-----------------------
                    *********************************** *                       

HsCD00297035        GTAC
NM_022162.1         ----
XM_005256084.1      ----
                        

Pathways

NCI : Canonical NF-kappaB pathway
Reactome : Activated TLR4 signalling
Reactome : Cytokine Signaling in Immune system
Reactome : Immune System
Reactome : Innate Immune System
Reactome : Interleukin-1 signaling
Reactome : JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Reactome : MAP kinase activation in TLR cascade
Reactome : MyD88 cascade initiated on plasma membrane
Reactome : MyD88 dependent cascade initiated on endosome
Reactome : MyD88-independent cascade
Reactome : MyD88:Mal cascade initiated on plasma membrane
Reactome : NOD1/2 Signaling Pathway
Reactome : Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome : Signaling by Interleukins
Reactome : TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Reactome : TRAF6 Mediated Induction of proinflammatory cytokines
Reactome : TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome : TRIF-mediated TLR3/TLR4 signaling
Reactome : Toll Like Receptor 10 (TLR10) Cascade
Reactome : Toll Like Receptor 2 (TLR2) Cascade
Reactome : Toll Like Receptor 3 (TLR3) Cascade
Reactome : Toll Like Receptor 4 (TLR4) Cascade
Reactome : Toll Like Receptor 5 (TLR5) Cascade
Reactome : Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome : Toll Like Receptor 9 (TLR9) Cascade
Reactome : Toll Like Receptor TLR1:TLR2 Cascade
Reactome : Toll Like Receptor TLR6:TLR2 Cascade
Reactome : Toll-Like Receptors Cascades
Reactome : activated TAK1 mediates p38 MAPK activation
WikiPathway : NOD pathway

Protein

SMART domain : LRR_RI : Leucine rich repeat, ribonuclease inhibitor type
UniProt : Q9HC29
HPRD : 05810

Clone

Cloning Information : 269707
HIP Master Clone ID : 201209
IMAGE ID : 100015951
Original Clone ID : FLH269707.01L

Organism


TAX_ID : 9606
Species Specific ID: 64127

Genome

Chromosome : 16
Map Location : 16q21
Ensembl : ENSG00000167207

Reagents

Labome : NOD2-antibody