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PTPN11 (Homo sapiens) in pSp64RI

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Explanation of Terms


Gene: Gene Symbol:  PTPN11
Gene Name:  protein tyrosine phosphatase, non-receptor type 11
Sequence             
Original Clone ID: None
Keyword: None
Species: Homo sapiens
Type: cDNA
Vector Name: pSp64RI               Format:  CLOSED
Source: Neel Lab
Description: None
Comments: None
Mutation/
Discrepancy :
Yes / Unknown
Publications: PMID: 10594032
Title: Activated mutants of SHP-2 preferrentially induce elongateion of Xenopus animal caps
Authors: Yongping Wang
Benjamin Neel
HsCD00009111

Price:  Login for Pricing
NOT AVAILABLE
Academic and non-profit labs
Special MTA: None

 


Coding Sequence Details
Insert Sequence Verified?: N Verification Method: 
Mutations:
D61A

Discrepancy:
None
5' Linker Sequence: None
3' Linker Sequence: None

 

 Recommended Growth Condition:

Distributed in bacterial strain : T1 phage resistant DH5-alpha
Antibiotic Selection: Host Type:  bacterial    Marker:  ampicillin
Bacterial Selection Condition:  100 ug/mL ampicillin
Growth Condition:  Growth with the single antibiotic in LB at 37 degrees is recommended.
Comments:  Commonly used conditions for ampicillin resistant plasmid clones.
Protein Expression Results: None
Recommended expression in: Not Applicable
       DyNA Vector Map

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Vector Name: pSp64RI

pSp64RI in advanced viewed

Synonyms: pSp64R1
Sequencing Primer: Forward:  Unknown
Reverse:  Unknown
Description: Eukaryotic (Xenopus-specific?) expression vector with X beta-globin 3p and 5p UTR; amp resistance; restriction enzyme cloning.
Comments: BamHI can be used to linearize plasmid for transcription with Sp6
Size (bp): 0
Parent Vector: Name: pSp64T
Description: pSp64T (PMID6700722) used to create pSp64RI (PMID7859288)
Empty Vector: None
Properties: in vitro transcription
Author Name: Terry Tang
Publications: PMID: 7859288
Title: The SH2-containing protein-tyrosine phosphatase SH-PTP2 is upstream of MAP kinase for early Xenopus development

Vector Map:         Vector Sequence:
Sequence: Not Available

 



Vector Features:

Type Name Description Start Position End Position
3pUTR globin 3pUTR Xenopus beta-globin 3 prime UTR (200bp flanked by XhoI PstI) 0 0
5pUTR globin 5pUTR Xenopus beta-globin 5 prime UTR (60bp flanked by HindII KpnI) 0 0
MCS MCS multiple cloning site of sorts use this to linearize EcoRI flanked inserts prior to in vitro transcription (PstI SalI XbaI BamHI SmaI SacI) 0 0
bacterial origin origin bacterial origin 0 0
selectable marker AmpR ampicillin resistance gene 0 0

 

  • Gene
  • Pathways
  • Protein
  • Organism
  • Genome

Gene

 

Gene Symbol : PTPN11
Symbol Nomenclature : PTPN11
SYNONYM : BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Designation : PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11
Full Nomenclature : protein tyrosine phosphatase, non-receptor type 11
GENEID : 5781
SYNONYM : pSp64RI-SHP1-D61A
SYNONYM : pSp64R1-SHP1-D61A
SYNONYM : pSp64RI-SHP-1-D61A
HGNC : 9644
MIM : 176876
Vega : OTTHUMG00000134334
Target GenBank: None

 

Pathways

NCI : Angiopoietin receptor Tie2-mediated signaling
NCI : CXCR4-mediated signaling events
NCI : EGF receptor (ErbB1) signaling pathway
NCI : EPO signaling pathway
NCI : ErbB2/ErbB3 signaling events
NCI : FGF signaling pathway
NCI : Fc-epsilon receptor I signaling in mast cells
NCI : GMCSF-mediated signaling events
NCI : IFN-gamma pathway
NCI : IGF1 pathway
NCI : IL2 signaling events mediated by PI3K
NCI : IL2 signaling events mediated by STAT5
NCI : IL2-mediated signaling events
NCI : IL3-mediated signaling events
NCI : IL5-mediated signaling events
NCI : IL6-mediated signaling events
NCI : Insulin Pathway
NCI : Integrins in angiogenesis
NCI : N-cadherin signaling events
NCI : Neurotrophic factor-mediated Trk receptor signaling
NCI : PDGFR-beta signaling pathway
NCI : SHP2 signaling
NCI : Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
NCI : Signaling events mediated by Stem cell factor receptor (c-Kit)
NCI : Signaling events mediated by VEGFR1 and VEGFR2
NCI : Signaling events regulated by Ret tyrosine kinase
NCI : TCR signaling in naïve CD4+ T cells
NCI : VEGFR1 specific signals
Reactome : Activated TLR4 signalling
Reactome : Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome : Adaptive Immune System
Reactome : Axon guidance
Reactome : CTLA4 inhibitory signaling
Reactome : Cell surface interactions at the vascular wall
Reactome : Cell-Cell communication
Reactome : Constitutive PI3K/AKT Signaling in Cancer
Reactome : Costimulation by the CD28 family
Reactome : Cytokine Signaling in Immune system
Reactome : DAP12 interactions
Reactome : DAP12 signaling
Reactome : Developmental Biology
Reactome : Disease
Reactome : Downstream signal transduction
Reactome : Downstream signaling events of B Cell Receptor (BCR)
Reactome : Downstream signaling of activated FGFR
Reactome : FRS2-mediated cascade
Reactome : Fc epsilon receptor (FCERI) signaling
Reactome : GAB1 signalosome
Reactome : Hemostasis
Reactome : IGF1R signaling cascade
Reactome : IRS-mediated signalling
Reactome : IRS-related events
Reactome : IRS-related events triggered by IGF1R
Reactome : Immune System
Reactome : Innate Immune System
Reactome : Insulin receptor signalling cascade
Reactome : Interferon Signaling
Reactome : Interferon alpha/beta signaling
Reactome : Interferon gamma signaling
Reactome : Interleukin-3, 5 and GM-CSF signaling
Reactome : Interleukin-6 signaling
Reactome : MyD88-independent cascade
Reactome : NGF signalling via TRKA from the plasma membrane
Reactome : Negative regulation of FGFR signaling
Reactome : Netrin mediated repulsion signals
Reactome : Netrin-1 signaling
Reactome : Nuclear signaling by ERBB4
Reactome : PD-1 signaling
Reactome : PECAM1 interactions
Reactome : PI-3K cascade
Reactome : PI3K Cascade
Reactome : PI3K events in ERBB2 signaling
Reactome : PI3K events in ERBB4 signaling
Reactome : PI3K/AKT Signaling in Cancer
Reactome : PI3K/AKT activation
Reactome : PIP3 activates AKT signaling
Reactome : Platelet homeostasis
Reactome : Platelet sensitization by LDL
Reactome : Prolactin receptor signaling
Reactome : Regulation of IFNA signaling
Reactome : Regulation of IFNG signaling
Reactome : Role of LAT2/NTAL/LAB on calcium mobilization
Reactome : Signal Transduction
Reactome : Signal regulatory protein (SIRP) family interactions
Reactome : Signaling by EGFR
Reactome : Signaling by EGFR in Cancer
Reactome : Signaling by ERBB2
Reactome : Signaling by ERBB4
Reactome : Signaling by FGFR
Reactome : Signaling by FGFR in disease
Reactome : Signaling by Insulin receptor
Reactome : Signaling by Interleukins
Reactome : Signaling by Leptin
Reactome : Signaling by PDGF
Reactome : Signaling by SCF-KIT
Reactome : Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome : Signaling by the B Cell Receptor (BCR)
Reactome : Signalling by NGF
Reactome : Spry regulation of FGF signaling
Reactome : TRIF-mediated TLR3/TLR4 signaling
Reactome : Tie2 Signaling
Reactome : Toll Like Receptor 3 (TLR3) Cascade
Reactome : Toll Like Receptor 4 (TLR4) Cascade
Reactome : Toll-Like Receptors Cascades
WikiPathway : Alpha 6 Beta 4 signaling pathway
WikiPathway : B Cell Receptor Signaling Pathway
WikiPathway : EGF/EGFR Signaling Pathway
WikiPathway : Heart Development
WikiPathway : IL-1 signaling pathway
WikiPathway : IL-2 Signaling pathway
WikiPathway : IL-3 Signaling Pathway
WikiPathway : IL-4 signaling pathway
WikiPathway : IL-5 signaling pathway
WikiPathway : IL-6 signaling pathway
WikiPathway : Insulin Signaling
WikiPathway : Kit receptor signaling pathway
WikiPathway : Leptin signaling pathway
WikiPathway : Prolactin Signaling Pathway
WikiPathway : Proteins and DNA Sequences in Cardicac Structures
WikiPathway : Signaling of Hepatocyte Growth Factor Receptor
WikiPathway : TCR Signaling Pathway
WikiPathway : Type II interferon signaling (IFNG)
WikiPathway : angiogenesis overview

Protein

HPRD : 01470

Organism


TAX_ID : 9606
Species Specific ID: 5781

Genome

Chromosome : 12
Map Location : 12q24
Ensembl : ENSG00000179295