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Argonne National Laboratory and National Cancer Institute Clinical Proteomic Technologies for Cancer
Basolateral cell membrane localized
Cystic fibrosis transmembrane conductance regulator (CFTR) collection (expression clones)
GPCR
Glyco-enzyme clone collection (in Gateway entry and expression vectors)
Human Cancer Protein Interaction Network
Human transcription factor collection (pLenti6.2/V5-DEST lentiviral vector)
Lipid modification enzymes
Membrane localized
Membrane protein
Mitochondrial carrier
Mitochondrial outer membrane protein
Mitochondrion inner membrane localized
Nitrogen Fixing
Phosohatases, pathogen
Phosphatases, human/rodent
Reagent
Recombinant antibodies
Small GTPase Pathway
Transporter
Ubiquitin-Like Domains

Signalling         Nuclear         Extracellular         Other        

Signalling

14_3_3	4.1m	ADF	ANK	ARF	ARM
ArfGap	B41	B561	BAG	BH4	BIR
BTK	B_lectin	C1	C2	CARD	CASc
CH	CNH	CULLIN	CYCc	Calx_beta	CheW
Cyt-b5	DAGKa	DAGKc	DAX	DEATH	DED
DEP	DSPc	DYNc	EAL	EFh	EH
ENTH	FBOX	FCH	FF	FH2	FHA
FIST	FYVE	GAF	GAS2	GED	GGDEF
GGL	GRAM	GS	G_alpha	GoLoco	GuKc
HAMP	HATPase_c	HECTc	HPT	HisKA	Hr1
ILWEQ	IPPc	IQ	ITAM	KISc	L27
LIM	LMWPc	MA	MIR	MYSc	MeTrc
MyTH4	PAC	PAS	PASTA	PBD	PDZ
PH	PI3K_C2	PI3K_p85B	PI3K_rbd	PI3Ka	PI3Kc
PIPKc	PLAc	PLCXc	PLCYc	PLDc	PP2Ac
PP2Cc	PTB	PTBI	PTPc	PTPc_motif	PX
PXA	RA	RAB	RAN	RAS	RBD
REC	RGS	RHO	RHOD	RIIa	RING
RIO	RanBD	RasGAP	RasGEF	RasGEFN	RhoGAP
RhoGEF	SAM	SAR	SEC14	SH2	SH3
SOCS	SPEC	SPRY	START	STAT_int	S_TK_X
S_TKc	Sec7	Small GTPase Pathway	TBC	TIR	TRASH
TarH	TyrKc	UBA	UBCc	UBQ	UBX
VHP	VHS	VPS9	WD40	WH1	WH2
WW	ZU5	ZnF_A20	ZnF_AN1	ZnF_RBZ	ZnF_UBP
ZnF_ZZ	acidPPc	cNMP	t_SNARE

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Nuclear

35EXOc	53EXOc	A1pp	ADEAMc	ANTAR	AP2
AP2Ec	APC2	ARID	AT_hook	AWS	AXH
AlkA_N	AraC_E_bind	B3	BAF	BAH	BASIC
BBC	BBOX	BCL	BEN	BHD_1	BHD_2
BHD_3	BING4CT	BOP1NT	BP28CT	BRCT	BRIGHT
BRK	BRLZ	BROMO	BSD	BTP	Bro-N
Brr6_like_C_C	C1_4	CAT_RBD	CBF	CDT1	CENPB
CG-1	CHK	CHROMO	CKS	CPDc	CPSF73-100_C
CRM1_C	CSP	CTD	CUT	CarD_TRCF	Cdc6_C
Cir_N	Copper-fist	Cu_FIST	D5_N	DDE_Tnp_IS1595	DDT
DEXDc	DM	DMAP_binding	DP	DSHCT	DSRM
DSX_dimer	DUF1087	DUF1693	DUF1744	DWA	DWB
DZF	ENDO3c	ERCC4	ETS	EXOIII	Elp3
Endonuclease_NS	FBD	FCD	FES	FH	FYRC
FYRN	Fapy_DNA_glyco	Ftsk_gamma	Fungal_trans	GIYc	G_patch
H15	H2A	H2B	H3	H4	HALZ
HDAC_interact	HELICc	HLH	HMG	HMG17	HNHc
HNS	HOLI	HOX	HRDC	HSA	HSF
HTH_ARAC	HTH_ARSR	HTH_ASNC	HTH_CRP	HTH_DEOR	HTH_DTXR
HTH_GNTR	HTH_ICLR	HTH_LACI	HTH_LUXR	HTH_MARR	HTH_MERR
HTH_XRE	HhH1	HhH2	IBN_N	IENR1	IENR2
IPT	IRF	IRO	JmjC	JmjN	KH
KOW	KRAB	Ku78	LEM	LIGANc	LNS2
LytTR	MA3	MADF	MADS	MBD	MBT
MCM	MUTSac	MUTSd	MutH	MutL_C	NEUZ
NGN	NOSIC	NurA	ORANGE	PAX	PAZ
PHD	POL3Bc	POLAc	POLBc	POLIIIAc	POLXc
POP4	POU	POX	PRE_C2HC	PRY	PSP
PUA	PUG	PUR	ParB	Piwi	Plus3
PostSET	PreSET	PriCT_1	Prim-Pol	RIBOc	RPOL4c
RPOL8c	RPOL9	RPOLA_N	RPOLCX	RPOLD	RPR
RQC	RRM	RWD	Resolvase	Rho_N	S4
SAND	SANT	SAP	SCAN	SET	SFM
SMC_hinge	SMR	SPK	SPT2	SRA	STE
Skp1	Sm	SpoVT_AbrB	TAF	TBOX	TDU
TEA	TFIIE	TFS2M	TFS2N	THAP	TIFY
TOP1Ac	TOP1Bc	TOP2c	TOP4c	TOPEUc	TOPRIM
TRCF	Telo_bind	Telomerase_RBD	Trans_reg_C	UDG	UME
UTRA	Ubox	XPGI	XPGN	YL1_C	YccV-like
YqgFc	Zalpha	ZnF_BED	ZnF_C2C2	ZnF_C2H2	ZnF_C2HC
ZnF_C3H1	ZnF_C4	ZnF_CHCC	ZnF_DBF	ZnF_GATA	ZnF_NFX
ZnF_PMZ	ZnF_Rad18	ZnF_U1	eIF5C	zf-AD

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Extracellular

A4_EXTRA	AAI	ACR	AIP3	ALBUMIN	AMA-1
AMOP	ANATO	APPLE	A_amylase_inhib	Aamy	Aamy_C
Aerolysin	Agglutinin	Amb_V_allergen	Amb_all	Ami_2	Ami_3
Asparaginase	Autotransporter	BID_1	BID_2	BON	BPI1
BPI2	Bet_v_1	BowB	C1Q	C345C	C4
C6	CA	CADG	CALCITONIN	CASH	CBD_II
CBD_IV	CCP	CFEM	CHASE	CHASE2	CHRD
CLECT	CLIP	CLa	CLb	CNX	COLFI
COLIPASE	CRF	CSF2	CT	CUB	CW
CY	Cache_2	ChW	ChtBD1	ChtBD2	ChtBD3
Col_cuticle_N	Connexin_CCC	Cutinase	CysPc	DEFSN	DISIN
DM4_12	DM6	DNaseIc	DSL	DoH	EGF
EGF_CA	EGF_Lam	END	EPEND	EPH_lbd	Excalibur
FA58C	FAS1	FBG	FGF	FIMAC	FN1
FN2	FN3	FOLN	FRI	FTP	FU
Flu_M1_C	G2F	GA	GASTRIN	GEL	GHA
GHB	GLA	GLECT	GLUCA	GPS	GRAN
Galanin	Glyco_10	Glyco_18	Glyco_25	Glyco_32	HX
HYDRO	Haemagg_act	HintC	HintN	HormR	IB
IFabd	IG	IGc1	IGc2	IGv	IL1
IL10	IL2	IL4_13	IL6	IL7	INB
IlGF	Inhibitor_I29	Int_alpha	JHBP	Jacalin	KAZAL
KR	KU	Kelch	Knot1	LCCL	LDLa
LIF_OSM	LINK	LPD_N	LRRCT	LRRNT	LRR_BAC
LRR_CC	LRR_RI	LRR_SD22	LRR_TYP	LU	LY
LYZ1	LYZ2	LamB	LamG	LamGL	LamNT
LysM	MACPF	MAM	MANEC	MATH	MD
MHC_II_alpha	MHC_II_beta	ML	NAT_PEP	NEAT	NGF
NH	NIDO	NL	NMU	NRF	NTR
NUC	OLF	OSTEO	P4Hc	PA2c	PAH
PAN_AP	PBP5_C	PBPb	PBPe	PD	PDGF
PGA_cap	PGRP	PKD	PLP	PQQ	PRP
PSA	PSI_domain	PTH	PTI	PTN	PTX
PbH1	Pept_C1	PhBP	RICIN	RNAse_Pc	SAA
SAPA	SCP	SCPU	SCY	SEA	SEL1
SERPIN	SF_P	SH3b	SO	SR	STI
STN	SapB	Sema	ShKT	TECPR	TGFB
THN	TK	TNF	TNFR	TR_FER	TR_THY
TSP1	TSPN	TSPc	TY	Tryp_SPc	UTG
VIT	VPS10	VWA	VWC	VWD	WAP
WIF	WNT1	WR1	WSC	X8	XTALbg
ZP	ZnMc	Zn_dep_PLPC	Zn_pept	btg1	fCBD
s48_45

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Other

AAA	AAA_PrkA	AARP2CN	ACTIN	AD	ADSL_C
AFOR_N	AGTRAP	AHS1	AHS2	AICARFT_IMPCHas	AIRC
AKAP_110	ALAD	AMPKBI	AMP_N	ANX	ASCH
Ad_cyc_g-alpha	Adenylsucc_synt	AdoHcyase	AdoHcyase_NAD	Agenet	Agouti
AgrB	AgrD	Agro_virD5	Aha1_N	AlaDh_PNT_C	AlaDh_PNT_N
Ala_racemase_C	AlcB	Ald_Xan_dh_C	Aldolase_II	Alpha-L-AF_C	Alpha-amyl_C2
Alpha-mann_mid	Alpha_L_fucos	Alpha_TIF	Alpha_adaptinC2	Alpha_kinase	Amelin
Amelogenin	Arfaptin	Arg_tRNA_synt_N	Arrestin_C	B12-binding_2	B2-adapt-app_C
B3_4	B5	BACK	BAR	BATS	BCS1_N
BHL	BLUF	BMC	BRICHOS	BRO1	BTAD
BTB	BURP	Bac_DnaA_C	Bac_rhodopsin	Beach	Beta-Casp
Beta-TrCP_D	BetaGal_dom2	Bgal_small_N	Biotin_carb_C	Brix	Btz
C8	CAD	CAMSAP_CKK	CAP10	CAP_GLY	CARP
CAT	CBM49	CBM_10	CBM_2	CBM_25	CBM_3
CBM_X	CBS	CDC37_C	CDC37_M	CDC37_N	CDC48_2
CDC48_N	CGGC	CHAD	CHB_HEX	CHZ	CK_II_beta
CLH	CM_2	COG6	CO_deh_flav_C	CP12	CPSase_L_D3
CPSase_sm_chain	CPW_WPC	CRA	CRAL_TRIO_N	CRISPR_assoc	CRS1_YhbY
CTLH	CTNS	CUE	CVNH	CXC	CYCLIN
CYTH	CaMBD	CaM_binding	Ca_chan_IQ	CactinC_cactus	Cadherin_pro
Candida_ALS_N	Carb_anhydrase	Catalase	Cation_ATPase_N	Cg6151-P	ChSh
Citrate_ly_lig	ClpB_D2-small	CoA_binding	CoA_trans	CobW_C	Cog4
CorC_HlyC	CpcD	Cpl-7	Cpn10	Cullin_Nedd8	Cupin_1
CxxC_CXXC_SSSS	Cyanate_lyase	D-ser_dehydrat	DALR_1	DALR_2	DBC1
DBP10CT	DBR1	DCD	DCP2	DCX	DDHD
DDRGK	DELLA	DENN	DEXDc2	DHDPS	DHHA2
DIL	DIRP	DKCLD	DM10	DM11	DM13
DM14	DM15	DM16	DM3	DM5	DM7
DM8	DM9	DPBB_1	DRY_EERY	DTW	DUF1041
DUF1086	DUF1220	DUF1237	DUF1338	DUF1518	DUF167
DUF1704	DUF1713	DUF1716	DUF1719	DUF1741	DUF1751
DUF1767	DUF1771	DUF1785	DUF1856	DUF1866	DUF1899
DUF1900	DUF1907	DUF1943	DUF1944	DUSP	Dabb
Dak1_2	Dak2	DeoC	DeoRC	DnaG_DnaB_bind	DnaJ
Drf_FH3	Drf_GBD	DysFC	DysFN	EB_dh	EF1_GNE
EFG_C	EFG_IV	EKR	ELFV_dehydrog	ETF	EZ_HEAT
Elong-fact-P_C	FABD	FDX-ACB	FMN_bind	FRG	Fe_hyd_SSU
FeoA	Flavin_Reduct	Flavokinase	FolB	FtsA	GAL4
GDNF	GIT	GYF	GYR	Gal-bind_lectin	GatB_Yqey
Germane	Gp_dh_N	Grip	HA2	HAT	HDc
HELICc2	HEPN	HIRAN	HTTM	HWE_HK	IBR
IDEAL	IG_FLMN	JAB_MPN	KIND	L51_S25_CI-B8	LA
LH2	LITAF	LON	LRRcap	Lactamase_B	LeuA_dimer
Lig_chan-Glu_bd	LisH	MGS	MIF4G	MIT	MORN
MR_MLE	Mad3_BUB1_I	Malic_M	MbtH	MgtE_N	MltA
MoCF_biosynth	Molybdop_Fe4S4	Mterf	NADH-G_4Fe-4S_3	NADH_4Fe-4S	NDK
NEBU	NIL	NPCBM	Nfu_N	OMPdecase	OmpH
P-II	PA14	PAM	PAW	PB1	PCRF
PGAM	PHB	PIG-X	PINT	PINc	PKS_AT
PKS_DH	PKS_ER	PKS_KR	PKS_KS	PKS_MT	PKS_PP
PKS_TE	PLEC	PMEI	PP2C_SIG	PROF	PSN
PWI	PWWP	PYNP_C	PepX_C	PepX_N	PhnA_Zn_Ribbon
PlsC	PolyA	Prim_Zn_Ribbon	Pro-kuma_activ	ProQ	ProRS-C_1
Pro_CA	Proteasome_A_N	Pumilio	QLQ	R3H	RAP
RES	RINGv	RL11	RNB	RPEL	RRM_1
RUN	RelA_SpoT	Robl_LC7	RuBisCO_small	S1	SAF
SAM_PNT	SATase_N	SEC63	SEP	SHR3_chaperone	SMI1_KNR4
SNc	SOCS_box	SRP54	SRP54_N	STI1	SWAP
SWIB	SecA_DEAD	SecA_PP_bind	Semialdhyde_dh	Sorb	Spc7
SpoU_sub_bind	SprT	SynN	T5orf172	TAFH	TAP_C
TGc	THEG	THUMP	THY	TLC	TLDc
TPK_B1_binding	TPR	TUDOR	TilS_C	Tim44	Transket_pyr
Tubulin	Tubulin_C	UAS	UBA_e1_C	UDPG_MGDP_dh_C	UIM
UreE_C	UreE_N	V4R	VKc	VRR_NUC	VWC_out
WGR	WHEP-TRS	WHy	WRKY	WSN	WWE
YceI	ZM	ZipA_C	ZnF_CDGSH	ZnF_TAZ	ZnF_TTF
ZnF_UBR1	Zpr1	alkPPc	c-SKI_SMAD_bind	calpain_III	cwf21
dDENN	eIF1a	eIF2B_5	eIF6	rADc	tRNA_SAD
uDENN	zf-C4_ClpX

NCI Database

Panther Database

Reactome Database

WikiPathway Database

NCI Pathways
ALK1 pathway	ALK1 signaling events
ALK2 signaling events	AP-1 transcription factor network
ATF-2 transcription factor network	ATM pathway
ATR signaling pathway	Alpha-synuclein signaling
Alpha4 beta1 integrin signaling events	Alpha6 beta4 integrin-ligand interactions
Alpha9 beta1 integrin signaling events	AlphaE beta7 integrin cell surface interactions
Alternative NF-kappaB pathway	Angiopoietin receptor Tie2-mediated signaling
Arf1 pathway	Arf6 downstream pathway
Arf6 signaling events	Arf6 trafficking events
Atypical NF-kappaB pathway	Aurora A signaling
Aurora B signaling	Aurora C signaling
BARD1 signaling events	BCR signaling pathway
BMP receptor signaling	Beta1 integrin cell surface interactions
Beta2 integrin cell surface interactions	Beta3 integrin cell surface interactions
Beta5 beta6 beta7 and beta8 integrin cell surface interactions	C-MYB transcription factor network
C-MYC pathway	CD40/CD40L signaling
CDC42 signaling events	CXCR3-mediated signaling events
CXCR4-mediated signaling events	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Calcium signaling in the CD4+ TCR pathway	Canonical NF-kappaB pathway
Canonical Wnt signaling pathway	Caspase Cascade in Apoptosis
Cellular roles of Anthrax toxin	Ceramide signaling pathway
Circadian rhythm pathway	Class I PI3K signaling events
Class I PI3K signaling events mediated by Akt	Class IB PI3K non-lipid kinase events
Coregulation of Androgen receptor activity	DNA-PK pathway in nonhomologous end joining
Degradation of beta catenin	Direct p53 effectors
Downstream signaling in naïve CD8+ T cells	E-cadherin signaling events
E-cadherin signaling in keratinocytes	E-cadherin signaling in the nascent adherens junction
E2F transcription factor network	EGF receptor (ErbB1) signaling pathway
EGFR-dependent Endothelin signaling events	EPHA forward signaling
EPHA2 forward signaling	EPHB forward signaling
EPO signaling pathway	Effects of Botulinum toxin
Endogenous TLR signaling	Endothelins
Ephrin A reverse signaling	Ephrin B reverse signaling
EphrinA-EPHA pathway	EphrinB-EPHB pathway
ErbB receptor signaling network	ErbB1 downstream signaling
ErbB2/ErbB3 signaling events	ErbB4 signaling events
FAS (CD95) signaling pathway	FGF signaling pathway
FOXA transcription factor networks	FOXA1 transcription factor network
FOXA2 and FOXA3 transcription factor networks	FOXM1 transcription factor network
Fanconi anemia pathway	Fc-epsilon receptor I signaling in mast cells
FoxO family signaling	GMCSF-mediated signaling events
Glucocorticoid receptor regulatory network	Glypican 1 network
Glypican 2 network	Glypican 3 network
Glypican pathway	HIF-1-alpha transcription factor network
HIF-2-alpha transcription factor network	HIV-1 Nef: Negative effector of Fas and TNF-alpha
Hedgehog signaling events mediated by Gli proteins	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
IFN-gamma pathway	IGF1 pathway
IL1-mediated signaling events	IL12 signaling mediated by STAT4
IL12-mediated signaling events	IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5	IL2-mediated signaling events
IL23-mediated signaling events	IL27-mediated signaling events
IL3-mediated signaling events	IL4-mediated signaling events
IL5-mediated signaling events	IL6-mediated signaling events
IL8- and CXCR1-mediated signaling events	IL8- and CXCR2-mediated signaling events
IL8-mediated signaling events	Insulin Pathway
Insulin-mediated glucose transport	Integrin family cell surface interactions
Integrin-linked kinase signaling	Integrins in angiogenesis
Internalization of ErbB1	JNK signaling in the CD4+ TCR pathway
LKB1 signaling events	LPA receptor mediated events
LPA4-mediated signaling events	Lissencephaly gene (LIS1) in neuronal migration and development
N-cadherin signaling events	Nectin adhesion pathway
Nephrin/Neph1 signaling in the kidney podocyte	Netrin-mediated signaling events
Neurotrophic factor-mediated Trk receptor signaling	Noncanonical Wnt signaling pathway
Nongenotropic Androgen signaling	Notch signaling pathway
Notch-mediated HES/HEY network	Osteopontin-mediated events
PAR1-mediated thrombin signaling events	PAR4-mediated thrombin signaling events
PDGF receptor signaling network	PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway	PLK1 signaling events
PLK2 and PLK4 events	PLK3 signaling events
Plasma membrane estrogen receptor signaling	Plexin-D1 Signaling
Polo-like kinase signaling events in the cell cycle	Posttranslational regulation of adherens junction stability and dissassembly
Presenilin action in Notch and Wnt signaling	Proteoglycan syndecan-mediated signaling events
RAC1 signaling pathway	RXR and RAR heterodimerization with other nuclear receptor
Rapid glucocorticoid signaling	Ras signaling in the CD4+ TCR pathway
Reelin signaling pathway	Regulation of Androgen receptor activity
Regulation of CDC42 activity	Regulation of RAC1 activity
Regulation of Ras family activation	Regulation of RhoA activity
Regulation of Telomerase	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Regulation of nuclear SMAD2/3 signaling	Regulation of nuclear beta catenin signaling and target gene transcription
Regulation of p38-alpha and p38-beta	Regulation of retinoblastoma protein
Retinoic acid receptors-mediated signaling	RhoA signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes	S1P1 pathway
S1P2 pathway	S1P3 pathway
S1P4 pathway	S1P5 pathway
SHP2 signaling	Signaling by Aurora kinases
Signaling events mediated by HDAC Class I	Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class III	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PRL	Signaling events mediated by PTP1B
Signaling events mediated by Stem cell factor receptor (c-Kit)	Signaling events mediated by TCPTP
Signaling events mediated by VEGFR1 and VEGFR2	Signaling events mediated by focal adhesion kinase
Signaling events mediated by the Hedgehog family	Signaling events regulated by Ret tyrosine kinase
Signaling mediated by p38-alpha and p38-beta	Signaling mediated by p38-gamma and p38-delta
Sphingosine 1-phosphate (S1P) pathway	Stabilization and expansion of the E-cadherin adherens junction
Sumoylation by RanBP2 regulates transcriptional repression	Syndecan-1-mediated signaling events
Syndecan-2-mediated signaling events	Syndecan-3-mediated signaling events
Syndecan-4-mediated signaling events	TCR signaling in naïve CD4+ T cells
TCR signaling in naïve CD8+ T cells	TGF-beta receptor signaling
TNF receptor signaling pathway	TRAIL signaling pathway
Thrombin/protease-activated receptor (PAR) pathway	Thromboxane A2 receptor signaling
Trk receptor signaling mediated by PI3K and PLC-gamma	Trk receptor signaling mediated by the MAPK pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling	VEGF and VEGFR signaling network
VEGFR1 specific signals	VEGFR3 signaling in lymphatic endothelium
Validated nuclear estrogen receptor alpha network	Validated nuclear estrogen receptor beta network
Validated targets of C-MYC transcriptional activation	Validated targets of C-MYC transcriptional repression
Validated transcriptional targets of AP1 family members Fra1 and Fra2	Validated transcriptional targets of TAp63 isoforms
Validated transcriptional targets of deltaNp63 isoforms	Visual signal transduction: Cones
Visual signal transduction: Rods	Wnt signaling network
a4b7 Integrin signaling	a6b1 and a6b4 Integrin signaling
amb2 Integrin signaling	mTOR signaling pathway
p38 MAPK signaling pathway	p38 signaling mediated by MAPKAP kinases
p53 pathway	p73 transcription factor network
p75(NTR)-mediated signaling

Panther Pathways Go to Top
2-arachidonoylglycerol biosynthesis
5-Hydroxytryptamine biosynthesis	5-Hydroxytryptamine degredation
5HT1 type receptor mediated signaling pathway	5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway	5HT4 type receptor mediated signaling pathway
ATP synthesis	Acetate utilization
Adenine and hypoxanthine salvage pathway	Adrenaline and noradrenaline biosynthesis
Alanine biosynthesis	Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway	Alzheimer disease-presenilin pathway
Aminobutyrate degradation	Anandamide degradation
Androgen/estrogene/progesterone biosynthesis	Angiogenesis
Angiotensin II-stimulated signaling through G proteins and beta-arrestin	Apoptosis signaling pathway
Arginine biosynthesis	Ascorbate degradation
Asparagine and aspartate biosynthesis	Axon guidance mediated by Slit/Robo
Axon guidance mediated by netrin	Axon guidance mediated by semaphorins
B cell activation	Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway	Beta3 adrenergic receptor signaling pathway
Blood coagulation	Bupropion degradation
Cadherin signaling pathway	Carnitine metabolism
Cell cycle	Cholesterol biosynthesis
Circadian clock system	Coenzyme A biosynthesis
Coenzyme A linked carnitine metabolism	Cortocotropin releasing factor receptor signaling pathway
Cysteine biosynthesis	Cytoskeletal regulation by Rho GTPase
DNA replication	De novo purine biosynthesis
De novo pyrimidine deoxyribonucleotide biosynthesis	De novo pyrimidine ribonucleotides biosythesis
Dopamine receptor mediated signaling pathway	EGF receptor signaling pathway
Endogenous cannabinoid signaling	Endothelin signaling pathway
Enkephalin release	FAS signaling pathway
FGF signaling pathway	Flavin biosynthesis
Formyltetrahydroformate biosynthesis	Fructose galactose metabolism
GABA-B receptor II signaling	Gamma-aminobutyric acid synthesis
General transcription by RNA polymerase I	General transcription regulation
Glutamine glutamate conversion	Glycolysis
Gonadotropin-releasing hormone receptor pathway	Hedgehog signaling pathway
Heme biosynthesis	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Histamine H1 receptor mediated signaling pathway	Histamine H2 receptor mediated signaling pathway
Histamine synthesis	Huntington disease
Hypoxia response via HIF activation	Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	Insulin/IGF pathway-protein kinase B signaling cascade
Integrin signalling pathway	Interferon-gamma signaling pathway
Interleukin signaling pathway	Ionotropic glutamate receptor pathway
Isoleucine biosynthesis	JAK/STAT signaling pathway
Leucine biosynthesis	Lipoate_biosynthesis
Mannose metabolism	Metabotropic glutamate receptor group I pathway
Metabotropic glutamate receptor group II pathway	Metabotropic glutamate receptor group III pathway
Methionine biosynthesis	Methylcitrate cycle
Methylmalonyl pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway	N-acetylglucosamine metabolism
Nicotine degradation	Nicotine pharmacodynamics pathway
Nicotinic acetylcholine receptor signaling pathway	Notch signaling pathway
O-antigen biosynthesis	Opioid prodynorphin pathway
Opioid proenkephalin pathway	Opioid proopiomelanocortin pathway
Ornithine degradation	Oxidative stress response
Oxytocin receptor mediated signaling pathway	P53 pathway feedback loops 1
PDGF signaling pathway	PI3 kinase pathway
Parkinson disease	Pentose phosphate pathway
Phenylethylamine degradation	Plasminogen activating cascade
Proline biosynthesis	Purine metabolism
Pyridoxal phosphate salvage pathway	Pyridoxal-5-phosphate biosynthesis
Pyrimidine Metabolism	Pyruvate metabolism
Ras Pathway	S-adenosylmethionine biosynthesis
Salvage pyrimidine deoxyribonucleotides	Salvage pyrimidine ribonucleotides
Serine glycine biosynthesis	Succinate to proprionate conversion
Sulfate assimilation	Synaptic vesicle trafficking
T cell activation	TCA cycle
TGF-beta signaling pathway	Tetrahydrofolate biosynthesis
Thiamin metabolism	Threonine biosynthesis
Thyrotropin-releasing hormone receptor signaling pathway	Toll receptor signaling pathway
Transcription regulation by bZIP transcription factor	Triacylglycerol metabolism
Ubiquitin proteasome pathway	VEGF signaling pathway
Valine biosynthesis	Vasopressin synthesis
Vitamin B6 metabolism	Vitamin D metabolism and pathway
Wnt signaling pathway	Xanthine and guanine salvage pathway
mRNA splicing	p38 MAPK pathway
p53 pathway	p53 pathway by glucose deprivation
p53 pathway feedback loops 2

Reactome Pathways Go to Top
2-LTR circle formation
3' -UTR-mediated translational regulation	5-Phosphoribose 1-diphosphate biosynthesis
A tetrasaccharide linker sequence is required for GAG synthesis	A third proteolytic cleavage releases NICD
ABC-family proteins mediated transport	ABCA transporters in lipid homeostasis
ABH2 mediated Reversal of Alkylation Damage	ABH3 mediated Reversal of Alkylation Damage
ADP signalling through P2Y purinoceptor 1	ADP signalling through P2Y purinoceptor 12
AKT phosphorylates targets in the cytosol	AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A	AMPK inhibits chREBP transcriptional activation activity
APC-Cdc20 mediated degradation of Nek2A	APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B	APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
APOBEC3G mediated resistance to HIV-1 infection	ARMS-mediated activation
ATF4 activates genes	ATF6-alpha activates chaperone genes
ATF6-alpha activates chaperones	ATM mediated phosphorylation of repair proteins
ATM mediated response to DNA double-strand break	ATP sensitive Potassium channels
AUF1 (hnRNP D0) destabilizes mRNA	Abacavir metabolism
Abacavir transmembrane transport	Abacavir transport and metabolism
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	Abnormal metabolism in phenylketonuria
Abortive elongation of HIV-1 transcript in the absence of Tat	Acetylation
Acetylcholine Binding And Downstream Events	Acetylcholine Neurotransmitter Release Cycle
Acetylcholine regulates insulin secretion	Acrosome Reaction
Activated NOTCH1 Transmits Signal to the Nucleus	Activated TLR4 signalling
Activated point mutants of FGFR2	Activation and oligomerization of BAK protein
Activation of AMPA receptors	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Activation of ATR in response to replication stress	Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins	Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria	Activation of C3 and C5
Activation of Ca-permeable Kainate Receptor	Activation of CaMK IV
Activation of DNA fragmentation factor	Activation of G protein gated Potassium channels
Activation of GABAB receptors	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Activation of Kainate Receptors upon glutamate binding	Activation of Matrix Metalloproteinases
Activation of NF-kappaB in B cells	Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of NMDA receptor upon glutamate binding and postsynaptic events	Activation of NOXA and translocation to mitochondria
Activation of Na-permeable Kainate Receptors	Activation of Nicotinic Acetylcholine Receptors
Activation of PKB	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of PUMA and translocation to mitochondria	Activation of RAS in B cells
Activation of Rac	Activation of TRKA receptors
Activation of caspases through apoptosome-mediated cleavage	Activation of gene expression by SREBF (SREBP)
Activation of the AP-1 family of transcription factors	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Activation of the phototransduction cascade	Activation of the pre-replicative complex
Activation, myristolyation of BID and translocation to mitochondria	Activation, translocation and oligomerization of BAX
Acyl chain remodeling of CL	Acyl chain remodeling of DAG and TAG
Acyl chain remodelling of PC	Acyl chain remodelling of PE
Acyl chain remodelling of PG	Acyl chain remodelling of PI
Acyl chain remodelling of PS	Adaptive Immune System
Adenosine P1 receptors	Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway	Adherens junctions interactions
Adrenaline signalling through Alpha-2 adrenergic receptor	Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors	Advanced glycosylation endproduct receptor signaling
Agmatine biosynthesis	Alpha-defensins
Alpha-oxidation of phytanate	Alternative complement activation
Amine Oxidase reactions	Amine compound SLC transporters
Amine ligand-binding receptors	Amine-derived hormones
Amino Acid conjugation	Amino acid and oligopeptide SLC transporters
Amino acid synthesis and interconversion (transamination)	Amino acid transport across the plasma membrane
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Amplification of signal from the kinetochores
Amyloids	Anchoring fibril formation
Androgen biosynthesis	Antagonism of Activin by Follistatin
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen processing-Cross presentation	Antigen processing: Ubiquitination & Proteasome degradation
Antiviral mechanism by IFN-stimulated genes	Apoptosis
Apoptosis induced DNA fragmentation	Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins	Apoptotic execution phase
Apoptotic factor-mediated response	Aquaporin-mediated transport
Arachidonate production from DAG	Arachidonic acid metabolism
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	Asparagine N-linked glycosylation
Assembly Of The HIV Virion	Assembly of Viral Components at the Budding Site
Assembly of collagen fibrils and other multimeric structures	Assembly of the ORC complex at the origin of replication
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks	Assembly of the RAD51-ssDNA nucleoprotein complex
Assembly of the pre-replicative complex	Association of TriC/CCT with target proteins during biosynthesis
Association of licensing factors with the pre-replicative complex	Astrocytic Glutamate-Glutamine Uptake And Metabolism
Asymmetric localization of PCP proteins	Attachment of GPI anchor to uPAR
Attenuation phase	Autodegradation of Cdh1 by Cdh1:APC/C
Autodegradation of the E3 ubiquitin ligase COP1	Autointegration results in viral DNA circles
Axon guidance	Axonal growth inhibition (RHOA activation)
Axonal growth stimulation	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
BMAL1:CLOCK,NPAS2 activates circadian gene expression	Base Excision Repair
Base-Excision Repair, AP Site Formation	Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
Basigin interactions	Beta defensins
Beta oxidation of butanoyl-CoA to acetyl-CoA	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of myristoyl-CoA to lauroyl-CoA	Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	Beta-catenin phosphorylation cascade
Beta-oxidation of pristanoyl-CoA	Beta-oxidation of very long chain fatty acids
Bicarbonate transporters	Bile acid and bile salt metabolism
Bile salt and organic anion SLC transporters	Binding and Uptake of Ligands by Scavenger Receptors
Binding and entry of HIV virion	Biological oxidations
Biosynthesis of A2E, implicated in retinal degradation	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Biotin transport and metabolism	Branched-chain amino acid catabolism
Breakdown of the nuclear lamina	Budding and maturation of HIV virion
Butyrate Response Factor 1 (BRF1) destabilizes mRNA	C6 deamination of adenosine
CD28 co-stimulation	CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway	CDC6 association with the ORC:origin complex
CDK-mediated phosphorylation and removal of Cdc6	CDO in myogenesis
CDT1 association with the CDC6:ORC:origin complex	CHL1 interactions
COPI Mediated Transport	COPII (Coat Protein 2) Mediated Vesicle Transport
COX reactions	CREB phosphorylation
CREB phosphorylation through the activation of Adenylate Cyclase	CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of CaMKK	CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling	CS/DS degradation
CTLA4 inhibitory signaling	CYP2E1 reactions
Ca-dependent events	Ca2+ activated K+ channels
Ca2+ pathway	CaM pathway
CaMK IV-mediated phosphorylation of CREB	Calcitonin-like ligand receptors
Calmodulin induced events	Calnexin/calreticulin cycle
Cam-PDE 1 activation	Cap-dependent Translation Initiation
Carnitine synthesis	Caspase-8 activation
Caspase-mediated cleavage of cytoskeletal proteins	Catecholamine biosynthesis
Cation-coupled Chloride cotransporters	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle	Cell Cycle Checkpoints
Cell Cycle, Mitotic	Cell death signalling via NRAGE, NRIF and NADE
Cell junction organization	Cell surface interactions at the vascular wall
Cell-Cell communication	Cell-cell junction organization
Cell-extracellular matrix interactions	Cellular Senescence
Cellular response to heat stress	Cellular response to hypoxia
Cellular responses to stress	Centrosome maturation
Ceramide signalling	ChREBP activates metabolic gene expression
Chaperonin-mediated protein folding	Chemokine receptors bind chemokines
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Cholesterol biosynthesis
Chondroitin sulfate biosynthesis	Chondroitin sulfate/dermatan sulfate metabolism
Chromatin modifying enzymes	Chromatin organization
Chromosome Maintenance	Chylomicron-mediated lipid transport
Circadian Clock	Citric acid cycle (TCA cycle)
Class A/1 (Rhodopsin-like receptors)	Class B/2 (Secretin family receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)	Class I MHC mediated antigen processing & presentation
Class II GLUTs	Classical Kir channels
Classical antibody-mediated complement activation	Clathrin derived vesicle budding
Clearance of Nuclear Envelope Membranes from Chromatin	Cleavage of Growing Transcript in the Termination Region
Cleavage of the damaged purine	Cleavage of the damaged pyrimidine
Cobalamin (Cbl, vitamin B12) transport and metabolism	Coenzyme A biosynthesis
Cohesin Loading onto Chromatin	Collagen biosynthesis and modifying enzymes
Collagen degradation	Collagen formation
Common Pathway	Complement cascade
Condensation of Prometaphase Chromosomes	Condensation of Prophase Chromosomes
Conjugation of benzoate with glycine	Conjugation of carboxylic acids
Conjugation of phenylacetate with glutamine	Conjugation of salicylate with glycine
Constitutive PI3K/AKT Signaling in Cancer	Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	Costimulation by the CD28 family
Creatine metabolism	Creation of C4 and C2 activators
Cross-presentation of particulate exogenous antigens (phagosomes)	Cross-presentation of soluble exogenous antigens (endosomes)
Crosslinking of collagen fibrils	Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry	Cyclin B2 mediated events
Cyclin D associated events in G1	Cyclin E associated events during G1/S transition
Cysteine formation from homocysteine	Cytochrome P450 - arranged by substrate type
Cytochrome c-mediated apoptotic response	Cytokine Signaling in Immune system
Cytosolic iron-sulfur cluster assembly	Cytosolic sensors of pathogen-associated DNA
Cytosolic sulfonation of small molecules	Cytosolic tRNA aminoacylation
DAG and IP3 signaling	DAP12 interactions
DAP12 signaling	DARPP-32 events
DCC mediated attractive signaling	DEx/H-box helicases activate type I IFN and inflammatory cytokines production
DNA Damage Bypass	DNA Damage Recognition in GG-NER
DNA Damage Reversal	DNA Damage/Telomere Stress Induced Senescence
DNA Repair	DNA Replication
DNA Replication Pre-Initiation	DNA replication initiation
DNA strand elongation	DSCAM interactions
Deadenylation of mRNA	Deadenylation-dependent mRNA decay
Death Receptor Signalling	Defective AMN causes hereditary megaloblastic anemia 1
Defective BTD causes biotidinase deficiency	Defective CD320 causes methylmalonic aciduria
Defective CUBN causes hereditary megaloblastic anemia 1	Defective GIF causes intrinsic factor deficiency
Defective HLCS causes multiple carboxylase deficiency	Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective MMAA causes methylmalonic aciduria type cblA	Defective MMAB causes methylmalonic aciduria type cblB
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective MUT causes methylmalonic aciduria mut type	Defective TCN2 causes hereditary megaloblastic anemia
Defects in biotin (Btn) metabolism	Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism	Defensins
Degradation of GABA	Degradation of beta-catenin by the destruction complex
Degradation of cysteine and homocysteine	Degradation of the extracellular matrix
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	Depolymerisation of the Nuclear Lamina
Deposition of new CENPA-containing nucleosomes at the centromere	Depurination
Depyrimidination	Dermatan sulfate biosynthesis
Detoxification of Reactive Oxygen Species	Developmental Biology
Digestion of dietary carbohydrate	Digestion of dietary lipid
Dimerization of procaspase-8	Disease
Diseases associated with visual transduction	Disinhibition of SNARE formation
Displacement of DNA glycosylase by APE1	Dissolution of Fibrin Clot
Dopamine Neurotransmitter Release Cycle	Dopamine clearance from the synaptic cleft
Dopamine receptors	Double-Strand Break Repair
Downregulation of ERBB2:ERBB3 signaling	Downregulation of ERBB4 signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Downregulation of TGF-beta receptor signaling
Downstream TCR signaling	Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)	Downstream signaling of activated FGFR
Dual incision reaction in GG-NER	Dual incision reaction in TC-NER
E2F mediated regulation of DNA replication	E2F-enabled inhibition of pre-replication complex formation
ECM proteoglycans	EGFR Transactivation by Gastrin
EGFR downregulation	EGFR interacts with phospholipase C-gamma
ER Quality Control Compartment (ERQC)	ER to Golgi Transport
ER-Phagosome pathway	ERK activation
ERK/MAPK targets	ERK1 activation
ERK2 activation	ERKs are inactivated
Early Phase of HIV Life Cycle	Effects of PIP2 hydrolysis
Eicosanoid ligand-binding receptors	Eicosanoids
Elastic fibre formation	Electric Transmission Across Gap Junctions
Electron transport from NADPH to Ferredoxin	Elevation of cytosolic Ca2+ levels
Elongation arrest and recovery	Endogenous sterols
Endosomal Sorting Complex Required For Transport (ESCRT)	Endosomal/Vacuolar pathway
Energy dependent regulation of mTOR by LKB1-AMPK	Entry of Influenza Virion into Host Cell via Endocytosis
Enzymatic degradation of Dopamine by monoamine oxidase	Enzymatic degradation of dopamine by COMT
Epigenetic regulation of gene expression	Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide	Establishment of Sister Chromatid Cohesion
Estrogen biosynthesis	Ethanol oxidation
Eukaryotic Translation Elongation	Eukaryotic Translation Initiation
Eukaryotic Translation Termination	Export of Viral Ribonucleoproteins from Nucleus
Extension of Telomeres	Extracellular matrix organization
Extrinsic Pathway	Extrinsic Pathway for Apoptosis
FBXW7 Mutants and NOTCH1 in Cancer	FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation	FCERI mediated NF-kB activation
FCGR activation	FGFR ligand binding and activation
FGFR1 ligand binding and activation	FGFR1b ligand binding and activation
FGFR1c and Klotho ligand binding and activation	FGFR1c ligand binding and activation
FGFR2 ligand binding and activation	FGFR2b ligand binding and activation
FGFR2c ligand binding and activation	FGFR3 ligand binding and activation
FGFR3b ligand binding and activation	FGFR3c ligand binding and activation
FGFR4 ligand binding and activation	FMO oxidizes nucleophiles
FRS2-mediated cascade	Facilitative Na+-independent glucose transporters
Factors involved in megakaryocyte development and platelet production	Fanconi Anemia pathway
FasL/ CD95L signaling	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Fatty Acyl-CoA Biosynthesis	Fatty acid, triacylglycerol, and ketone body metabolism
Fatty acids	Fc epsilon receptor (FCERI) signaling
Fcgamma receptor (FCGR) dependent phagocytosis	Fertilization
Fibronectin matrix formation	Ficolins bind to repetitive carbohydrate structures on the target cell surface
Folding of actin by CCT/TriC	Formation of ATP by chemiosmotic coupling
Formation of Fibrin Clot (Clotting Cascade)	Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat	Formation of RNA Pol II elongation complex
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Formation of a pool of free 40S subunits
Formation of annular gap junctions	Formation of apoptosome
Formation of editosomes by ADAR proteins	Formation of incision complex in GG-NER
Formation of the Early Elongation Complex	Formation of the Editosome
Formation of the HIV-1 Early Elongation Complex	Formation of the active cofactor, UDP-glucuronate
Formation of the ternary complex, and subsequently, the 43S complex	Formation of transcription-coupled NER (TC-NER) repair complex
Formation of tubulin folding intermediates by CCT/TriC	Formyl peptide receptors bind formyl peptides and many other ligands
Free fatty acid receptors	Free fatty acids regulate insulin secretion
Frs2-mediated activation	Fructose catabolism
G alpha (12/13) signalling events	G alpha (i) signalling events
G alpha (q) signalling events	G alpha (s) signalling events
G alpha (z) signalling events	G beta:gamma signalling through PI3Kgamma
G beta:gamma signalling through PLC beta	G protein gated Potassium channels
G-protein activation	G-protein beta:gamma signalling
G-protein mediated events	G0 and Early G1
G1 Phase	G1/S DNA Damage Checkpoints
G1/S Transition	G1/S-Specific Transcription
G2 Phase	G2/M Checkpoints
G2/M DNA damage checkpoint	G2/M DNA replication checkpoint
G2/M Transition	GAB1 signalosome
GABA A (rho) receptor activation	GABA A receptor activation
GABA B receptor activation	GABA receptor activation
GABA synthesis	GABA synthesis, release, reuptake and degradation
GP1b-IX-V activation signalling	GPCR downstream signaling
GPCR ligand binding	GPVI-mediated activation cascade
GRB2 events in EGFR signaling	GRB2 events in ERBB2 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins	GRB7 events in ERBB2 signaling
GTP hydrolysis and joining of the 60S ribosomal subunit	Galactose catabolism
Gamma-carboxylation of protein precursors	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Gap junction assembly	Gap junction degradation
Gap junction trafficking	Gap junction trafficking and regulation
Gap-filling DNA repair synthesis and ligation in GG-NER	Gap-filling DNA repair synthesis and ligation in TC-NER
Gastrin-CREB signalling pathway via PKC and MAPK	Gene Expression
Generation of second messenger molecules	Generic Transcription Pathway
Global Genomic NER (GG-NER)	Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Glucagon-type ligand receptors
Glucocorticoid biosynthesis	Gluconeogenesis
Glucose metabolism	Glucose transport
Glucuronidation	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Glutamate Neurotransmitter Release Cycle	Glutathione conjugation
Glutathione synthesis and recycling	Glycerophospholipid biosynthesis
Glycogen breakdown (glycogenolysis)	Glycogen storage diseases
Glycogen synthesis	Glycolysis
Glycoprotein hormones	Glycosaminoglycan metabolism
Glycosphingolipid metabolism	Glyoxylate metabolism
Golgi Associated Vesicle Biogenesis	Golgi Cisternae Pericentriolar Stack Reorganization
Golgi to ER Retrograde Transport	Growth hormone receptor signaling
HATs acetylate histones	HCN channels
HDL-mediated lipid transport	HIV Infection
HIV Life Cycle	HIV Transcription Elongation
HIV Transcription Initiation	HIV elongation arrest and recovery
HS-GAG biosynthesis	HS-GAG degradation
HSF1 activation	HSF1-dependent transactivation
Heme biosynthesis	Heme degradation
Hemostasis	Heparan sulfate/heparin (HS-GAG) metabolism
Hexose transport	Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Highly sodium permeable acetylcholine nicotinic receptors
Histamine receptors	Histidine catabolism
Homologous DNA pairing and strand exchange	Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks	Hormone ligand-binding receptors
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	Host Interactions of HIV factors
Host Interactions with Influenza Factors	HuR stabilizes mRNA
Hyaluronan biosynthesis and export	Hyaluronan metabolism
Hyaluronan uptake and degradation	Hydrolysis of LPC
Hydrolysis of LPE	Hydroxycarboxylic acid-binding receptors
Hypusine synthesis from eIF5A-lysine	IGF1R signaling cascade
IKK complex recruitment mediated by RIP1	IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	IRE1alpha activates chaperones
IRF3 mediated activation of type 1 IFN	IRF3-mediated induction of type I IFN
IRS activation	IRS-mediated signalling
IRS-related events	IRS-related events triggered by IGF1R
ISG15 antiviral mechanism	Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Import of palmitoyl-CoA into the mitochondrial matrix
Inactivation of APC/C via direct inhibition of the APC/C complex	Inactivation of Cdc42 and Rac
Inactivation, recovery and regulation of the phototransduction cascade	Incretin synthesis, secretion, and inactivation
Inflammasomes	Influenza Infection
Influenza Life Cycle	Influenza Viral RNA Transcription and Replication
Influenza Virus Induced Apoptosis	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inhibition of HSL	Inhibition of Host mRNA Processing and RNA Silencing
Inhibition of PKR	Inhibition of TSC complex formation by PKB
Inhibition of adenylate cyclase pathway	Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	Initial triggering of complement
Initiation of Nuclear Envelope Reformation	Innate Immune System
Inositol phosphate metabolism	Inositol transporters
Insulin effects increased synthesis of Xylulose-5-Phosphate	Insulin processing
Insulin receptor recycling	Insulin receptor signalling cascade
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Integration of energy metabolism
Integration of provirus	Integration of viral DNA into host genomic DNA
Integrin alphaIIb beta3 signaling	Integrin cell surface interactions
Interaction With Cumulus Cells	Interaction With The Zona Pellucida
Interaction between L1 and Ankyrins	Interactions of Rev with host cellular proteins
Interactions of Tat with host cellular proteins	Interactions of Vpr with host cellular proteins
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	Interconversion of polyamines
Interferon Signaling	Interferon alpha/beta signaling
Interferon gamma signaling	Interleukin receptor SHC signaling
Interleukin-1 processing	Interleukin-1 signaling
Interleukin-2 signaling	Interleukin-3, 5 and GM-CSF signaling
Interleukin-6 signaling	Interleukin-7 signaling
Intrinsic Pathway	Intrinsic Pathway for Apoptosis
Inwardly rectifying K+ channels	Ion channel transport
Ion transport by P-type ATPases	Ionotropic activity of Kainate Receptors
Iron uptake and transport	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
KSRP destabilizes mRNA	Keratan sulfate biosynthesis
Keratan sulfate degradation	Keratan sulfate/keratin metabolism
Ketone body metabolism	Kinesins
Klotho-mediated ligand binding	L13a-mediated translational silencing of Ceruloplasmin expression
L1CAM interactions	LDL-mediated lipid transport
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	Lagging Strand Synthesis
Laminin interactions	Late Phase of HIV Life Cycle
Latent infection of Homo sapiens with Mycobacterium tuberculosis	Leading Strand Synthesis
Lectin pathway of complement activation	Leukotriene receptors
Ligand-gated ion channel transport	Linoleic acid (LA) metabolism
Lipid digestion, mobilization, and transport	Lipoprotein metabolism
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Loss of Function of SMAD2/3 in Cancer	Loss of Function of SMAD4 in Cancer
Loss of Function of TGFBR1 in Cancer	Loss of Function of TGFBR2 in Cancer
Loss of Nlp from mitotic centrosomes	Loss of proteins required for interphase microtubule organizationÿ from the centrosome
Lysine catabolism	Lysosome Vesicle Biogenesis
Lysosphingolipid and LPA receptors	M Phase
M/G1 Transition	MAP kinase activation in TLR cascade
MAPK targets/ Nuclear events mediated by MAP kinases	MASTL Facilitates Mitotic Progression
MEK activation	MHC class II antigen presentation
MPS I - Hurler syndrome	MPS II - Hunter syndrome
MPS IIIA - Sanfilippo syndrome A	MPS IIIB - Sanfilippo syndrome B
MPS IIIC - Sanfilippo syndrome C	MPS IIID - Sanfilippo syndrome D
MPS IV - Morquio syndrome A	MPS IV - Morquio syndrome B
MPS IX - Natowicz syndrome	MPS VI - Maroteaux-Lamy syndrome
MPS VII - Sly syndrome	MRN complex relocalizes to nuclear foci
Meiosis	Meiotic recombination
Meiotic synapsis	Membrane Trafficking
Membrane binding and targetting of GAG proteins	Metabolism
Metabolism of Angiotensinogen to Angiotensins	Metabolism of RNA
Metabolism of amino acids and derivatives	Metabolism of carbohydrates
Metabolism of folate and pterines	Metabolism of lipids and lipoproteins
Metabolism of mRNA	Metabolism of nitric oxide
Metabolism of non-coding RNA	Metabolism of nucleotides
Metabolism of polyamines	Metabolism of porphyrins
Metabolism of proteins	Metabolism of serotonin
Metabolism of steroid hormones and vitamin D	Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors	Metal ion SLC transporters
Methionine salvage pathway	Methylation
MicroRNA (miRNA) biogenesis	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Mineralocorticoid biosynthesis	Minus-strand DNA synthesis
Miscellaneous substrates	Mitochondrial ABC transporters
Mitochondrial Fatty Acid Beta-Oxidation	Mitochondrial Uncoupling Proteins
Mitochondrial biogenesis	Mitochondrial iron-sulfur cluster biogenesis
Mitochondrial protein import	Mitochondrial tRNA aminoacylation
Mitochondrial transcription initiation	Mitochondrial transcription termination
Mitotic Anaphase	Mitotic G1-G1/S phases
Mitotic G2-G2/M phases	Mitotic M-M/G1 phases
Mitotic Metaphase and Anaphase	Mitotic Metaphase/Anaphase Transition
Mitotic Prometaphase	Mitotic Prophase
Mitotic Spindle Checkpoint	Mitotic Telophase/Cytokinesis
Molecules associated with elastic fibres	Molybdenum cofactor biosynthesis
Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2	Mtb iron assimilation by chelation
Mucopolysaccharidoses	Multifunctional anion exchangers
Muscarinic acetylcholine receptors	Muscle contraction
MyD88 cascade initiated on plasma membrane	MyD88 dependent cascade initiated on endosome
MyD88-independent cascade	MyD88:Mal cascade initiated on plasma membrane
Myoclonic epilepsy of Lafora	Myogenesis
N-Glycan antennae elongation	N-glycan antennae elongation in the medial/trans-Golgi
N-glycan trimming and elongation in the cis-Golgi	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
NADE modulates death signalling	NADPH regeneration
NCAM signaling for neurite out-growth	NCAM1 interactions
NEP/NS2 Interacts with the Cellular Export Machinery	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
NF-kB is activated and signals survival	NFG and proNGF binds to p75NTR
NGF processing	NGF signalling via TRKA from the plasma membrane
NGF-independant TRKA activation	NICD traffics to nucleus
NOD1/2 Signaling Pathway	NOSIP mediated eNOS trafficking
NOSTRIN mediated eNOS trafficking	NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus	NOTCH2 intracellular domain regulates transcription
NRAGE signals death through JNK	NRIF signals cell death from the nucleus
NS1 Mediated Effects on Host Pathways	Na+-dependent glucose transporters
Na+/Cl- dependent neurotransmitter transporters	Nectin/Necl trans heterodimerization
Nef Mediated CD4 Down-regulation	Nef Mediated CD8 Down-regulation
Nef and signal transduction	Nef mediated downregulation of CD28 cell surface expression
Nef mediated downregulation of MHC class I complex cell surface expression	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Negative epigenetic regulation of rRNA expression	Negative regulation of FGFR signaling
Negative regulation of the PI3K/AKT network	Negative regulators of RIG-I/MDA5 signaling
Nephrin interactions	Netrin mediated repulsion signals
Netrin-1 signaling	Neurofascin interactions
Neuronal System	Neurophilin interactions with VEGF and VEGFR
Neurotoxicity of clostridium toxins	Neurotransmitter Clearance In The Synaptic Cleft
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	Neurotransmitter Release Cycle
Neurotransmitter uptake and Metabolism In Glial Cells	Nicotinamide salvaging
Nicotinate metabolism	Nitric oxide stimulates guanylate cyclase
NoRC negatively regulates rRNA expression	Non-integrin membrane-ECM interactions
Nonhomologous End-joining (NHEJ)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD)
Norepinephrine Neurotransmitter Release Cycle	Notch-HLH transcription pathway
NrCAM interactions	Nuclear Envelope Breakdown
Nuclear Envelope Reassembly	Nuclear Events (kinase and transcription factor activation)
Nuclear Pore Complex (NPC) Disassembly	Nuclear Receptor transcription pathway
Nuclear import of Rev protein	Nuclear signaling by ERBB4
Nucleosome assembly	Nucleotide Excision Repair
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Nucleotide-like (purinergic) receptors
O-glycosylation of TSR domain-containing proteins	O-linked glycosylation
O-linked glycosylation of mucins	O2/CO2 exchange in erythrocytes
Olfactory Signaling Pathway	Oligomerization of connexins into connexons
Oncogene Induced Senescence	Opioid Signalling
Opsins	Orc1 removal from chromatin
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Organelle biogenesis and maintenance
Organic anion transport	Organic anion transporters
Organic cation transport	Organic cation/anion/zwitterion transport
Other semaphorin interactions	Oxidative Stress Induced Senescence
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
P2Y receptors	PCP/CE pathway
PD-1 signaling	PDE3B signalling
PECAM1 interactions	PERK regulates gene expression
PI Metabolism	PI and PC transport between ER and Golgi membranes
PI-3K cascade	PI3K Cascade
PI3K events in ERBB2 signaling	PI3K events in ERBB4 signaling
PI3K/AKT Signaling in Cancer	PI3K/AKT activation
PIP3 activates AKT signaling	PKA activation
PKA activation in glucagon signalling	PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors	PKB-mediated events
PLC beta mediated events	PLC-gamma1 signalling
PLC-mediated hydrolysis of PIP2	PLCG1 events in ERBB2 signaling
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
PP2A-mediated dephosphorylation of key metabolic factors	PPARA activates gene expression
PRC2 methylates histones and DNA	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Packaging Of Telomere Ends	Passive transport by Aquaporins
Pausing and recovery of HIV elongation	Pausing and recovery of Tat-mediated HIV elongation
Pentose phosphate pathway (hexose monophosphate shunt)	Peptide chain elongation
Peptide hormone biosynthesis	Peptide hormone metabolism
Peptide ligand-binding receptors	Peroxisomal lipid metabolism
Phagosomal maturation (early endosomal stage)	Phase 1 - Functionalization of compounds
Phase II conjugation	Phenylalanine and tyrosine catabolism
Phosphate bond hydrolysis by NUDT proteins	Phospholipase C-mediated cascade
Phospholipid metabolism	Phosphorylation of CD3 and TCR zeta chains
Phosphorylation of Emi1	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	Phosphorylation of the APC/C
Plasmalogen biosynthesis	Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)	Platelet activation, signaling and aggregation
Platelet calcium homeostasis	Platelet degranulation
Platelet homeostasis	Platelet sensitization by LDL
Plus-strand DNA synthesis	Polo-like kinase mediated events
Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs	Polymerase switching
Polymerase switching on the C-strand of the telomere	Post NMDA receptor activation events
Post-Elongation Processing of Intron-Containing pre-mRNA	Post-Elongation Processing of Intronless pre-mRNA
Post-Elongation Processing of the Transcript	Post-chaperonin tubulin folding pathway
Post-transcriptional silencing by small RNAs	Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification	Postsynaptic nicotinic acetylcholine receptors
Potassium Channels	Potassium transport channels
Pre-NOTCH Expression and Processing	Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in the Endoplasmic Reticulum	Pre-NOTCH Transcription and Translation
Prefoldin mediated transfer of substrate to CCT/TriC	Pregnenolone biosynthesis
Presynaptic function of Kainate receptors	Presynaptic nicotinic acetylcholine receptors
Presynaptic phase of homologous DNA pairing and strand exchange	Processing and activation of SUMO
Processing of Capped Intron-Containing Pre-mRNA	Processing of Capped Intronless Pre-mRNA
Processing of DNA double-strand break ends	Processing of DNA ends prior to end rejoining
Processing of Intronless Pre-mRNAs	Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
Prolactin receptor signaling	Proline catabolism
Prolonged ERK activation events	Propionyl-CoA catabolism
Prostacyclin signalling through prostacyclin receptor	Prostanoid ligand receptors
Protein folding	Proton-coupled monocarboxylate transport
Proton-coupled neutral amino acid transporters	Proton/oligonucleotide cotransporters
Purine catabolism	Purine metabolism
Purine ribonucleoside monophosphate biosynthesis	Purine salvage
Pyrimidine biosynthesis	Pyrimidine catabolism
Pyrimidine metabolism	Pyrimidine salvage reactions
Pyrophosphate hydrolysis	Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle	RAF activation
RAF phosphorylates MEK	RAF/MAP kinase cascade
REV-ERBA represses gene expression	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIP-mediated NFkB activation via ZBP1	RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase I Chain Elongation	RNA Polymerase I Promoter Clearance
RNA Polymerase I Promoter Escape	RNA Polymerase I Promoter Opening
RNA Polymerase I Transcription	RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Termination	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase II HIV Promoter Escape	RNA Polymerase II Pre-transcription Events
RNA Polymerase II Promoter Escape	RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation	RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Termination	RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Chain Elongation	RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation	RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter	RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Termination	RORA activates circadian gene expression
RSK activation	Rap1 signalling
Ras activation uopn Ca2+ infux through NMDA receptor	Reactions specific to the complex N-glycan synthesis pathway
Reactions specific to the hybrid N-glycan synthesis pathway	Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
Recognition and association of DNA glycosylase with site containing an affected purine	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Recruitment of NuMA to mitotic centrosomes	Recruitment of mitotic centrosome proteins and complexes
Recruitment of repair and signaling proteins to double-strand breaks	Recycling of bile acids and salts
Recycling of eIF2:GDP	Recycling pathway of L1
Reduction of cytosolic Ca++ levels	Regulated proteolysis of p75NTR
Regulation by TREX1	Regulation by c-FLIP
Regulation of AMPK activity via LKB1	Regulation of APC/C activators between G1/S and early anaphase
Regulation of Apoptosis	Regulation of Commissural axon pathfinding by Slit and Robo
Regulation of Complement cascade	Regulation of DNA replication
Regulation of Glucokinase by Glucokinase Regulatory Protein	Regulation of HSF1-mediated heat shock response
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	Regulation of IFNA signaling
Regulation of IFNG signaling	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Regulation of KIT signaling	Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of PLK1 Activity at G2/M Transition	Regulation of Rheb GTPase activity by AMPK